Advances in The Research of P53 Pulses
文献类型：期刊论文
| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
 |
| 出版日期 | 2015 |
| 卷号 | 42 |
| 关键词 | DNA-DAMAGE RESPONSE P53-MDM2 FEEDBACK LOOP CELL-FATE SINGLE CELLS REGULATORY NETWORK DYNAMICS DEATH OSCILLATIONS ACTIVATION THRESHOLD P53 pulses DNA damage p53-Mdm2 negative feedback loop dynamics threshold cell fate |
| ISSN号 | 1000-3282 |
| 其他题名 | Advances in The Research of P53 Pulses |
| 英文摘要 | P53 pulses refer to the fluctuation of the p53 protein levels in the cells in a periodic or repetitive manner. The mechanisms for triggering P53 pulses lie in several kinds of the positive and negative feedback loops in the p53 network. Two core feedback loops include the p53-Mdm2 negative feedback loop and Wipl-ATM-p53 negative feedback loop. Owing to the existence of these feedback loops, a limit cycle and a given number of P53 pulses were generated when the p53 system entered the limit cycle region. Pro-apoptotic regulator and P53 existing in different form are gradually accumulated as the number of P53 pulses increases and then the irreversible cell fate is determined by opening apoptotic "switch" above the threshold level. The cell fate can be determined by the number of P53 pulses partly, but it also has close relationship with its frequency, amplitude and wave form. Therefore, it is of great significance for the mechanism investigation of diseases development, prevention and treatment. |
| 资助项目 | [National Natural Science Foundation of China] ; [Natural Science Foundation of Sichuan Province] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5356695 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/66977]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 推荐引用方式 GB/T 7714 | . Advances in The Research of P53 Pulses[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2015,42. |
| APA | (2015).Advances in The Research of P53 Pulses.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,42. |
| MLA | "Advances in The Research of P53 Pulses".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 42(2015). |
入库方式： OAI收割
来源：合肥物质科学研究院
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