The formation of intracellular nanoparticles correlates with cisplatin resistance
文献类型：期刊论文
| 刊名 | SCIENCE CHINA-MATERIALS
 |
| 出版日期 | 2015 |
| 卷号 | 58 |
| 关键词 | GLUTATHIONE-S-TRANSFERASE SQUAMOUS-CELL CARCINOMA LOCALLY ADVANCED HEAD PLATINUM NANOPARTICLES NECK-CANCER MOLECULAR-MECHANISMS DRUG-RESISTANCE CHEMOTHERAPY CYTOTOXICITY NANOMATERIALS |
| ISSN号 | 2095-8226 |
| 其他题名 | The formation of intracellular nanoparticles correlates with cisplatin resistance |
| 英文摘要 | Patients treated with the cisplatin often develop strong resistance to the drug after prolonged treatments, ultimately resulting in limited clinical efficacy. One of the possible mechanisms is that the internalized compound may be inactivated before getting access to the nucleus where cisplatin forms a complex with the genomic DNA and triggers a cell death program. However, the nature and intracellular fate of inactivated cisplatin is poorly illustrated. In the present study, we reported for the first time the presence of platinum nanoparticles (Pt-NPs) in the cytoplasm of cells treated with cisplatin. Further analysis also evidenced a correlation of the increased intracellular Pt-NPs formation with cisplatin resistance, and confirmed the process was glutathione S-transferase relevant. Our data suggest that tumor cells may develop cisplatin resistance by converting the drug into less toxic intracellular Pt-NPs, thereby impeding the drug from targeting its substrates. |
| 资助项目 | [National Key Basic Research Program of China] ; [National Natural Science Foundation of China (NSFC)] ; [Special Funds of National Natural Science Foundation of China For Basic Research Projects of Scientific Instruments] ; [Special Project on the Development of National Key Scientific Instruments and Equipment of China] ; [China Postdoctoral Science Foundation] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5530252 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/66524]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 推荐引用方式 GB/T 7714 | . The formation of intracellular nanoparticles correlates with cisplatin resistance[J]. SCIENCE CHINA-MATERIALS,2015,58. |
| APA | (2015).The formation of intracellular nanoparticles correlates with cisplatin resistance.SCIENCE CHINA-MATERIALS,58. |
| MLA | "The formation of intracellular nanoparticles correlates with cisplatin resistance".SCIENCE CHINA-MATERIALS 58(2015). |
入库方式： OAI收割
来源：合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。