Everolimus and zoledronic acid-a potential synergistic treatment for lung adenocarcinoma bone metastasis
文献类型：期刊论文
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2014 |
| 卷号 | 46 |
| 关键词 | HORMONE-RELATED PROTEIN MULTIPLE-MYELOMA CELLS BREAST-CANCER PHASE-II PROSTATE-CANCER MAMMALIAN TARGET ADVANCED NSCLC SCID MICE IN-VITRO BISPHOSPHONATES zoledronic acid everolimus lung adenocarcinoma bone metastasis |
| ISSN号 | 1672-9145 |
| 其他题名 | Everolimus and zoledronic acid-a potential synergistic treatment for lung adenocarcinoma bone metastasis |
| 英文摘要 | Non-small-cell lung cancer (NSCLC) frequently metasta-sizes to bone. It is known that zoledronic acid is cytostatic to tumors, and everolimus, the inhibitor for mammalian target of the rapamycin, could inhibit many types of cancer. Herein, we evaluated the effect of zoledronic acid alone and in combination with everolimus on treating lung adenocarcinoma bone metastasis in vitro and in vivo. Mice treated with zoledronic acid in combination with everolimus had more apoptotic lung cancer cells and more cells were arrested in the G1/G0 phase. The phosphorylation of p70S6K was inhibited in the combination treatment group. Lung cancer cell invasion was also significantly inhibited in the group with combination treatment in vitro. Bone nuclear scans revealed more metastatic lesions in controls compared with those in the combination treatment group. Bone scans and radiographic images indicated that combination therapy significantly reduced bone metastasis. The moderate survival rate suggested that the drug combination was synergistic, which can. delay NSCLC bone metastasis and prolong survival in vivo. |
| 资助项目 | [Wu Jie Ping-Roche Medical Special Foundation] ; [International Cooperation Projects by the Chinese Ministry of Science and Technology] ; [National High Technology Research and Development Program of China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5247023 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/64065]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 推荐引用方式 GB/T 7714 | . Everolimus and zoledronic acid-a potential synergistic treatment for lung adenocarcinoma bone metastasis[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2014,46. |
| APA | (2014).Everolimus and zoledronic acid-a potential synergistic treatment for lung adenocarcinoma bone metastasis.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,46. |
| MLA | "Everolimus and zoledronic acid-a potential synergistic treatment for lung adenocarcinoma bone metastasis".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 46(2014). |
入库方式： OAI收割
来源：合肥物质科学研究院
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