Effect of brain-derived neurotropic factor released from hypoxic astrocytes on gamma-aminobutyric acid type A receptor function in normal hippocampal neurons
文献类型：期刊论文
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2011 |
| 卷号 | 6 |
| 关键词 | CEREBRAL-ISCHEMIA GERBIL HIPPOCAMPUS GABA(A) RECEPTORS CL-COTRANSPORTER RAT-BRAIN BDNF EXPRESSION ACTIVATION GLUTAMATE NEUROPROTECTION brain-derived neurotrophic factor hypoxia astrocytes neurons gamma-aminobutyric acid type A receptor Na+-K+-Cl- cotransporter |
| ISSN号 | 1673-5374 |
| 其他题名 | Effect of brain-derived neurotropic factor released from hypoxic astrocytes on gamma-aminobutyric acid type A receptor function in normal hippocampal neurons |
| 英文摘要 | Astrocytes can release increased levels of brain-derived neurotrophic factor during cerebral ischemia, but it is unclear whether brain-derived neurotrophic factor affects gamma-aminobutyric acid type A receptor function in normal neurons. Results from this study demonstrated that gamma-aminobutyric acid at 100 mu mol/L concentration raised the intracellular calcium level in neurons treated with medium from cultured hypoxic astrocytes, and the rise in calcium level could be inhibited by gamma-aminobutyric acid type A receptor antagonist bicuculline or brain-derived neurotrophic factor receptor antagonist k252a. gamma-aminobutyric acid type A-gated current induced by 100 mu mol/L gamma-aminobutyric acid was in an inward direction in physiological conditions, but shifted to the outward direction in neurons when treated with the medium from cultured hypoxic astrocytes, and this effect could be inhibited by k252a. The reverse potential was shifted leftward to -93 mV, which could be inhibited by k252a and Na+-K+-Cl- cotransporter inhibitor bumetanide. Brain-derived neurotrophic factor was released from hypoxic astrocytes at a high level. It shifted the reverse potential of gamma-aminobutyric acid type A-gated currents leftward in normal neurons by enhancing the function of Na+-K+-Cl- cotransporter, and caused gamma-aminobutyric acid to exert an excitatory effect by activating gamma-aminobutyric acid type A receptor. |
| 资助项目 | [National Natural Science Foundation of China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4363500 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/63905]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 推荐引用方式 GB/T 7714 | . Effect of brain-derived neurotropic factor released from hypoxic astrocytes on gamma-aminobutyric acid type A receptor function in normal hippocampal neurons[J]. NEURAL REGENERATION RESEARCH,2011,6. |
| APA | (2011).Effect of brain-derived neurotropic factor released from hypoxic astrocytes on gamma-aminobutyric acid type A receptor function in normal hippocampal neurons.NEURAL REGENERATION RESEARCH,6. |
| MLA | "Effect of brain-derived neurotropic factor released from hypoxic astrocytes on gamma-aminobutyric acid type A receptor function in normal hippocampal neurons".NEURAL REGENERATION RESEARCH 6(2011). |
入库方式： OAI收割
来源：合肥物质科学研究院
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