CCGD-ESCC: A Comprehensive Database for Genetic Variants Associated with Esophageal Squamous Cell Carcinoma in Chinese Population
文献类型：期刊论文
| 刊名 | GENOMICS PROTEOMICS & BIOINFORMATICS
 |
| 出版日期 | 2018 |
| 卷号 | 16 |
| 关键词 | GENOME-WIDE ASSOCIATION SUSCEPTIBILITY LOCI CANCER STATISTICS LANDSCAPE SURVIVAL PLCE1 Esophageal cancer Germline variants Somatic mutations Association database Chinese population |
| ISSN号 | 1672-0229 |
| 其他题名 | CCGD-ESCC: A Comprehensive Database for Genetic Variants Associated with Esophageal Squamous Cell Carcinoma in Chinese Population |
| 英文摘要 | Esophageal squamous-cell carcinoma (ESCC) is one of the most lethal malignancies in the world and occurs at particularly higher frequency in China. While several genome-wide association studies (GWAS) of germline variants and whole-genome or whole-exome sequencing studies of somatic mutations in ESCC have been published, there is no comprehensive database publically available for this cancer. Here, we developed the Chinese Cancer Genomic Database-Esophageal Squamous Cell Carcinoma (CCGD-ESCC) database, which contains the associations of 69,593 single nucleotide polymorphisms (SNPs) with ESCC risk in 2022 cases and 2039 controls, survival time of 1006 ESCC patients (survival GWAS) and gene expression (expression quantitative trait loci, eQTL) in 94 ESCC patients. Moreover, this database also provides the associations between 8833 somatic mutations and survival time in 675 ESCC patients. Our user-friendly database is a resource useful for biologists and oncologists not only in identifying the associations of genetic variants or somatic mutations with the development and progression of ESCC but also in studying the underlying mechanisms for tumorigenesis of the cancer. CCGD-ESCC is freely accessible at http://db.cbi.pku.edu.cn/ccgd/ESCCdb. |
| 资助项目 | [CAMS Innovation Fund for Medical Sciences] ; [National Key RD Program] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6352974 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/63811]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 推荐引用方式 GB/T 7714 | . CCGD-ESCC: A Comprehensive Database for Genetic Variants Associated with Esophageal Squamous Cell Carcinoma in Chinese Population[J]. GENOMICS PROTEOMICS & BIOINFORMATICS,2018,16. |
| APA | (2018).CCGD-ESCC: A Comprehensive Database for Genetic Variants Associated with Esophageal Squamous Cell Carcinoma in Chinese Population.GENOMICS PROTEOMICS & BIOINFORMATICS,16. |
| MLA | "CCGD-ESCC: A Comprehensive Database for Genetic Variants Associated with Esophageal Squamous Cell Carcinoma in Chinese Population".GENOMICS PROTEOMICS & BIOINFORMATICS 16(2018). |
入库方式： OAI收割
来源：合肥物质科学研究院
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