The prognostic role of PRUNE2 in leiomyosarcoma
文献类型：期刊论文
| 刊名 | CHINESE JOURNAL OF CANCER
 |
| 出版日期 | 2013 |
| 卷号 | 32 |
| 关键词 | SOFT-TISSUE LEIOMYOSARCOMA BCH DOMAIN EXPRESSION TUMORS BNIP2 BMCC1 GENE Leiomyosarcoma PRUNE2 survival prognosis |
| ISSN号 | 1000-467X |
| 其他题名 | The prognostic role of PRUNE2 in leiomyosarcoma |
| 英文摘要 | PRUNE2 plays an important role in regulating tumor cell differentiation, proliferation, and invasiveness in neuroblastoma. Our previous study revealed that PRUNE2/OBSCN two-gene relative expression classifer accurately differentiated leiomyosarcoma from gastrointestinal stromal tumor. However, the association between PRUNE2 expression and prognosis in leiomyosarcoma is poorly understood. In this study, we evaluated the prognostic role of PRUNE2 in leiomyosarcoma. PRUNE2 expression was detected using immunohistochemistry in 30 formalin-fixed, paraffin-embedded leiomyosarcoma tissues from MD Anderson Cancer Center, and high expression was detected in 36.7% (11/30) of the samples. To validate these results, immunohistochemistry was performed on another cohort of 45 formalin-fixed, paraffin-embedded leiomyosarcoma tissues from Tianjin Medical University Cancer Institute & Hospital, and high PRUNE2 protein expression was detected in 37.8% (17/45) of the samples. Moreover, elevated PRUNE2 expression was significantly associated with tumor size (P = 0.03) and hemorrhage/cyst (P = 0.014), and was an independent favorable prognostic factor for overall survival in leiomyosarcoma patients from Tianjin Medical University Cancer Institute & Hospital (P < 0.05). These data suggest that increased PRUNE2 protein expression may serve as a favorable prognostic marker in human leiomyosarcoma. |
| 资助项目 | [National Nature Science Foundation of China] ; [University Cancer Foundation via the Sister Institution Network Fund (SINF) at the Tianjin Medical University Cancer Institute & Hospital (TMUCIH)] ; [Fudan University Shanghai Cancer Center (FUSCC)] ; [University of Texas MD Anderson Cancer Center (UTMDACC)] ; [Changjiang Scholars and Innovative Research Team in University (PCSIRT) in China] ; [National Key Scientific and Technological Project] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5007773 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/62773]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 推荐引用方式 GB/T 7714 | . The prognostic role of PRUNE2 in leiomyosarcoma[J]. CHINESE JOURNAL OF CANCER,2013,32. |
| APA | (2013).The prognostic role of PRUNE2 in leiomyosarcoma.CHINESE JOURNAL OF CANCER,32. |
| MLA | "The prognostic role of PRUNE2 in leiomyosarcoma".CHINESE JOURNAL OF CANCER 32(2013). |
入库方式： OAI收割
来源：合肥物质科学研究院
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