Serum ficolin-2 concentrations are significantly changed in patients with hepatitis B virus infection and liver diseases
文献类型：期刊论文
| 刊名 | VIROLOGICA SINICA
 |
| 出版日期 | 2015 |
| 卷号 | 30 |
| 关键词 | MANNAN-BINDING LECTIN VIRAL-HEPATITIS INNATE IMMUNITY COMPLEMENT FIBROSIS CLONING GENE ficolin-2 chronic hepatitis B (CHB) hepatocellular carcinoma (HCC) |
| ISSN号 | 1674-0769 |
| 其他题名 | Serum ficolin-2 concentrations are significantly changed in patients with hepatitis B virus infection and liver diseases |
| 英文摘要 | Human ficolin-2 is an important lectin complement pathway activator that is secreted from liver cells and has been implicated as an anti-infection innate immune molecule. However, the role of ficolin-2 protein and its dynamic changes over the course of and in the prognosis of chronic hepatitis B (CHB) and hepatocellular carcinoma (HCC) remain unclear. In this study, we analyzed ficolin-2 protein expression in a cohort of individuals with CHB infection, HCC and cirrhosis. A sandwich enzyme-linked immunosorbent assay (ELISA) method was used to measure serum ficolin-2 concentrations. Ficolin-2 expression in liver tissues was detected by immunohistochemical staining. Serum ficolin-2 concentrations in CHB patients were significantly higher than in healthy controls and HBV carriers. After 48 weeks of routine amelioration liver function treatment, serum ficolin-2 concentrations decreased and were positively correlated with favorable alanine aminotransferase (ALT), HBV DNA and HBeAg-seroconversion outcomes. Interestingly, we observed much lower expression of serum and intrahepatic ficolin-2 in HCC and cirrhosis compared with healthy controls. Our findings suggest that serum and intrahepatic ficolin-2 levels may be considered one of the indicators for the response of chronic HBV infection, HCC and cirrhosis. |
| 资助项目 | [National Natural Science Foundation of China] ; [National Outstanding Youth Foundation of China] ; [973 Program of China] ; [Program for Changjiang Scholars and Innovative Research Team in University] ; [Hubei Province's Outstanding Medical Academic Leader Program] ; [Development Fund for Collaborative Innovation Center of Glycoscience of Shandong University] ; [Science and Technology Program of Wuhan] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5517283 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/59332]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 推荐引用方式 GB/T 7714 | . Serum ficolin-2 concentrations are significantly changed in patients with hepatitis B virus infection and liver diseases[J]. VIROLOGICA SINICA,2015,30. |
| APA | (2015).Serum ficolin-2 concentrations are significantly changed in patients with hepatitis B virus infection and liver diseases.VIROLOGICA SINICA,30. |
| MLA | "Serum ficolin-2 concentrations are significantly changed in patients with hepatitis B virus infection and liver diseases".VIROLOGICA SINICA 30(2015). |
入库方式： OAI收割
来源：合肥物质科学研究院
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