Tobacco, air pollution, environmental carcinogenesis, and thoughts on conquering strategies of lung cancer
文献类型：期刊论文
| 刊名 | CANCER BIOLOGY & MEDICINE
 |
| 出版日期 | 2019 |
| 卷号 | 16 |
| 关键词 | NF-KAPPA-B SOMATIC MUTATIONS GENOMIC VARIATIONS CIGARETTE-SMOKE GENE-EXPRESSION NEVER INFLAMMATION PROFILES RISK ADENOCARCINOMA Lung cancer tobacco smoke air pollution smohaze carcinogenesis |
| ISSN号 | 2095-3941 |
| 英文摘要 | Each year there will be an estimated 2.1 million new lung cancer cases and 1.8 million lung cancer deaths worldwide. Tobacco smoke is the No.1 risk factors of lung cancer, accounting for > 85% lung cancer deaths. Air pollution, or haze, comprises ambient air pollution and household air pollution, which are reported to cause 252,000 and 304,000 lung cancer deaths each year, respectively. Tobacco smoke and haze (hereafter, smohaze) contain fine particles originated from insufficient combustion of biomass or coal, have quite similar carcinogens, and cause similar diseases. Smohaze exert hazardous effects on exposed populations, including induction of a large amount of mutations in the genome, alternative splicing of mRNAs, abnormalities in epigenomics, initiation of tumor-promoting chronic inflammation, and facilitating immune escape of transformed cells. Tackling smohaze and development of multi-targets-based preventive and therapeutic approaches targeting smohaze-induced carcinogenesis are the key to conquer lung cancer in the future. |
| 资助项目 | [National Key Research and Development Program of China] ; [National Natural Science Funds for Distinguished Young Scholar] ; [Key Project of the National Natural Science Foundation of China] ; [CAMS Innovation Fund for Medical Sciences] ; [National Natural Science Foundation of China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6647837 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/59269]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 推荐引用方式 GB/T 7714 | . Tobacco, air pollution, environmental carcinogenesis, and thoughts on conquering strategies of lung cancer[J]. CANCER BIOLOGY & MEDICINE,2019,16. |
| APA | (2019).Tobacco, air pollution, environmental carcinogenesis, and thoughts on conquering strategies of lung cancer.CANCER BIOLOGY & MEDICINE,16. |
| MLA | "Tobacco, air pollution, environmental carcinogenesis, and thoughts on conquering strategies of lung cancer".CANCER BIOLOGY & MEDICINE 16(2019). |
入库方式： OAI收割
来源：合肥物质科学研究院
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