XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer
文献类型：期刊论文
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2009 |
| 卷号 | 41 |
| 关键词 | NUCLEOTIDE-EXCISION-REPAIR PIGMENTOSUM GROUP-F XERODERMA-PIGMENTOSUM DNA-REPAIR GROUP-A TRANSCRIPTION RISK BINDING ERCC1 RNA single nucleotide polymorphism gene-chip XPA XPG nucleotide excision repair non-small cell lung cancer chemotherapy |
| ISSN号 | 1672-9145 |
| 其他题名 | XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer |
| 英文摘要 | DNA repair capacity (DRC) is correlated with sensitivity of cancer cells toward platinum-based chemotherapy. We hypothesize that genetic polymorphisms in DNA repair gene XPA (xeroderma pigmentosum group A) and XPG (xeroderma pigmentosum group G) (ERCC5, excision repair cross-complementation group 5), which result in inter-individual differences in DNA repair efficiency, may predict clinical response to platinum agents in advanced non-small cell lung cancer (NSCLC) patients. In this study, we find that the A -> G change of XPA A23G polymorphism significantly increased response to platinum-based chemotherapy. Polymorphism in XPG His46His was associated with a decreased treatment response, but was not statistically significant. |
| 资助项目 | [Jiangsu Province Nature Fund] ; [Medicine Science Technology Research 'Eleventh Five-Year' Program of PLA] ; [Focal Project of Nanjing Medicine Technology Development] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3613398 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/59146]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 推荐引用方式 GB/T 7714 | . XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2009,41. |
| APA | (2009).XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,41. |
| MLA | "XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 41(2009). |
入库方式： OAI收割
来源：合肥物质科学研究院
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