Analysis of circulating regulatory T cells (CD4(+)CD25(+)CD127(-)) after cryosurgery in prostate cancer
文献类型：期刊论文
| 刊名 | ASIAN JOURNAL OF ANDROLOGY
 |
| 出版日期 | 2013 |
| 卷号 | 15 |
| 关键词 | BREAST-CANCER IMMUNOLOGICAL RESPONSE SUPPRESSIVE FUNCTION PERIPHERAL-BLOOD DENDRITIC CELLS ANTIGEN 4 CRYOABLATION TUMOR MODULATION THERAPY cryosurgery immune response prostate cancer (PCa) regulatory T cell (Tregs) |
| ISSN号 | 1008-682X |
| 其他题名 | Analysis of circulating regulatory T cells (CD4 + CD25 + CD127 ? ) after cryosurgery in prostate cancer |
| 英文摘要 | This study was performed to assess the response of regulatory T cells (Tregs) following cryosurgery in prostate cancer (PCa) patients by measuring their frequency and immune function. Blood was collected prior to and at 4 and 8 weeks after treatment in 30 patients with high-risk PCa who underwent cryosurgery and from 15 healthy volunteers. Circulating CD4(+)CD25(+)CD127(-) Tregs were isolated. Their frequency was detected by flow cytometry, and immune suppressive function was evaluated by measuring the proliferation of CD4(+)CD25(-) T cells cocultured with Tregs. The results showed that the percentage of circulating CD4(+)CD25(+)CD127(-) Tregs was increased in PCa patients compared to healthy volunteers (7.6%+/- 0.73% vs. 5.8%+/- 0.54%, P<0.001). The frequency of circulating CD4(+)CD25(+)CD127(-) Tregs was reduced 4 weeks after cryosurgery compared to before surgery (6.3%+/- 0.58% vs. 7.6%+/- 0.73%, P<0.001), and the decrease persisted for 8 weeks. However, the suppressive function of Tregs was increased in eight of 12 patients, which might contribute to cancer recurrence. Then the response of circulating Tregs is complicated after cryosurgery for PCa, and further studies are warranted. |
| 资助项目 | [National Natural Science Foundation of China] ; [Tianjin Health Bureau Foundation of China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4876113 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/58998]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 推荐引用方式 GB/T 7714 | . Analysis of circulating regulatory T cells (CD4(+)CD25(+)CD127(-)) after cryosurgery in prostate cancer[J]. ASIAN JOURNAL OF ANDROLOGY,2013,15. |
| APA | (2013).Analysis of circulating regulatory T cells (CD4(+)CD25(+)CD127(-)) after cryosurgery in prostate cancer.ASIAN JOURNAL OF ANDROLOGY,15. |
| MLA | "Analysis of circulating regulatory T cells (CD4(+)CD25(+)CD127(-)) after cryosurgery in prostate cancer".ASIAN JOURNAL OF ANDROLOGY 15(2013). |
入库方式： OAI收割
来源：合肥物质科学研究院
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