Attenuated LKB1-SIK1 signaling promotes epithelial-mesenchymal transition and radioresistance of non-small cell lung cancer cells
文献类型：期刊论文
| 刊名 | CHINESE JOURNAL OF CANCER
 |
| 出版日期 | 2016 |
| 卷号 | 35 |
| 关键词 | LIVER KINASE B1 BREAST-CANCER CADHERIN EXPRESSION LKB1 METASTASIS INVASION Radioresistance Lung cancer Metastasis Epithelial-mesenchymal transition LKB1 SIK1 |
| ISSN号 | 1000-467X |
| 其他题名 | Attenuated LKB1-SIK1 signaling promotes epithelial-mesenchymal transition and radioresistance of non–small cell lung cancer cells |
| 英文摘要 | Background: Radiotherapy is one of the main therapeutic approaches for non-small cell lung cancer (NSCLC). However, radioresistant cancer cells can eventually cause tumor relapse and even fatal metastasis. It is thought that radioresistance and metastasis could be potentially linked by epithelial-mesenchymal transition (EMT). In this study, we established radioresistant NSCLC cells to investigate the potential relationship among radioresistance, EMT, and enhanced metastatic potential and the underlying mechanism involving liver kinase B1 (LKB1)-Salt-inducible kinase 1 (SIK1) signaling. |
| 资助项目 | [Jiangsu Provincial Department of Human Resources and Social Security under the "Six Talent Peaks" Project] ; [Jiangsu Provincial Commission of Health and Family Planning under the Project of Science and Technology] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5841944 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/58902]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 推荐引用方式 GB/T 7714 | . Attenuated LKB1-SIK1 signaling promotes epithelial-mesenchymal transition and radioresistance of non-small cell lung cancer cells[J]. CHINESE JOURNAL OF CANCER,2016,35. |
| APA | (2016).Attenuated LKB1-SIK1 signaling promotes epithelial-mesenchymal transition and radioresistance of non-small cell lung cancer cells.CHINESE JOURNAL OF CANCER,35. |
| MLA | "Attenuated LKB1-SIK1 signaling promotes epithelial-mesenchymal transition and radioresistance of non-small cell lung cancer cells".CHINESE JOURNAL OF CANCER 35(2016). |
入库方式： OAI收割
来源：合肥物质科学研究院
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