Maternal Genistein Intake Can Reduce Body Weight in Male Offspring
文献类型：期刊论文
| 刊名 | BIOMEDICAL AND ENVIRONMENTAL SCIENCES
 |
| 出版日期 | 2015 |
| 卷号 | 28 |
| 关键词 | RATS EXPOSURE PREGNANCY DIET |
| ISSN号 | 0895-3988 |
| 其他题名 | Maternal Genistein Intake Can Reduce Body Weight in Male Offspring |
| 英文摘要 | The study objectives were to investigate the relationship between early exposure to genistein and obesity in young adulthood and to evaluate changes in reproductive health during puberty and adulthood following in utero exposure to genistein. Thirty-two female rats were randomized into four groups; low dose 400 mg genistein/kg diet group (LG), mid-dose 1200 mg genistein/kg diet group (MG), high dose 3600 mg genistein/kg diet group (HG), and control group without genistein diet (CON). Rats were fed genistein at the beginning of pregnancy along with a high-fat diet. Pups were sacrificed at week 4 and week 8 after birth. High performance liquid chromatography (HPLC) results showed a correlation between maternal genistein intake and genistein concentration in pups' plasma. Compared to CON, body weight reduced significantly in male HG group at week 8. No statistical differences were found in plasma estradiol (E2), testosterone (T), interleukin (IL)-6, and C-reactive protein (CRP) levels with early genistein exposure. Furthermore, uterine histopathology showed notable changes in groups HG and MG compared with CON at week 4 and week 8. In conclusion, maternal genistein supplement could reduce body weight in male pups and alter uterine histopathology in female pups. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5563733 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/56473]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 推荐引用方式 GB/T 7714 | . Maternal Genistein Intake Can Reduce Body Weight in Male Offspring[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2015,28. |
| APA | (2015).Maternal Genistein Intake Can Reduce Body Weight in Male Offspring.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,28. |
| MLA | "Maternal Genistein Intake Can Reduce Body Weight in Male Offspring".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 28(2015). |
入库方式： OAI收割
来源：合肥物质科学研究院
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