Tumor suppressor miR-128-3p inhibits metastasis and epithelial-mesenchymal transition by targeting ZEB1 in esophageal squamous-cell cancer
文献类型：期刊论文
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2018 |
| 卷号 | 50 |
| 关键词 | ACUTE LYMPHOBLASTIC-LEUKEMIA GENOME-WIDE ASSOCIATION EMT-ACTIVATOR ZEB1 CIRCULATING MICRORNAS TRANSCRIPTION FACTORS PROMOTES INVASION MIRNA EXPRESSION FEEDBACK LOOP CARCINOMA SURVIVAL miR-128-3p esophageal squamous-cell carcinoma ZEB1 epithelial-mesenchymal transition invasion and metastasis |
| ISSN号 | 1672-9145 |
| 其他题名 | Tumor suppressor miR-128-3p inhibits metastasis and epithelial-mesenchymal transition by targeting ZEB1 in esophageal squamous-cell cancer |
| 英文摘要 | MicroRNAs (miRNAs) are some short RNAs that regulate multiple biological functions at post-transcriptional levels, such as tumorigenic processes, inflammatory lesions and cell apoptosis. Zinc finger E-box binding homeobox factor 1 (ZEB1) is a crucial mediator of epithelial-mesenchymal transition (EMT). It induces malignant progression of various cancers including human esophageal squamous-cell carcinoma (ESCC). In this study, we found that miR-128-3p was downregulated in ESCC tissues and cells by using PCR. Moreover, down-regulated expression of miR-128-3p was testified to be associated with poor prognosis of ESCC patients and might be regarded as an independent prognostic factor. Then, we examined the role of miR-128-3p in ESCC cells, and found that miR-128-3p could suppress the cell migration and invasion in vitro. Furthermore, ZEB1 was confirmed to be a direct target of miR-128-3p by luciferase reporter assay. Rescue experiments proved that EMT was regulated by miR-128-3p via suppression of ZEB1. Taken all together, we conclude that miR-128-3p suppresses EMT and metastasis via ZEB1, and miR-128-3p may be a critical mediator in ESCC. |
| 资助项目 | [Foundation of Sichuan Province] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6273052 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/52051]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 推荐引用方式 GB/T 7714 | . Tumor suppressor miR-128-3p inhibits metastasis and epithelial-mesenchymal transition by targeting ZEB1 in esophageal squamous-cell cancer[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2018,50. |
| APA | (2018).Tumor suppressor miR-128-3p inhibits metastasis and epithelial-mesenchymal transition by targeting ZEB1 in esophageal squamous-cell cancer.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,50. |
| MLA | "Tumor suppressor miR-128-3p inhibits metastasis and epithelial-mesenchymal transition by targeting ZEB1 in esophageal squamous-cell cancer".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 50(2018). |
入库方式： OAI收割
来源：合肥物质科学研究院
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