Brain-derived neurotrophic factor induces neuron-like cellular differentiation of mesenchymal stem cells derived from human umbilical cord blood cells in vitro
文献类型：期刊论文
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2011 |
| 卷号 | 6 |
| 关键词 | BONE-MARROW STROMAL CELLS PROGENITOR CELLS GROWTH PLASTICITY INDUCTION TISSUE EXPRESSION DENDRITE CULTURES human umbilical cord blood purification and culture brain-derived neurotrophic factor neuron-like cells neural regeneration |
| ISSN号 | 1673-5374 |
| 其他题名 | Brain-derived neurotrophic factor induces neuron-like cellular differentiation of mesenchymal stem cells derived from human umbilical cord blood cells in vitro |
| 英文摘要 | Human umbilical cord blood was collected from full-term deliveries scheduled for cesarean section. Mononuclear cells were isolated, amplified and induced as mesenchymal stem cells. Isolated mesenchymal stem cells tested positive for the marker CD29, CD44 and CD105 and negative for typical hematopoietic and endothelial markers. Following treatment with neural induction medium containing brain-derived neurotrophic factor for 7 days, the adherent cells exhibited neuron-like cellular morphology. Immunohistochemical staining and reverse transcription-PCR revealed that the induced mesenchymal stem cells expressed the markers for neuron-specific enolase and neurofilament. The results demonstrated that human umbilical cord blood-derived mesenchymal stem cells can differentiate into neuron-like cells induced by brain-derived neurotrophic factor in vitro. |
| 资助项目 | [National Basic Research Program of China (973 Program)] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4258106 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/48906]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 推荐引用方式 GB/T 7714 | . Brain-derived neurotrophic factor induces neuron-like cellular differentiation of mesenchymal stem cells derived from human umbilical cord blood cells in vitro[J]. NEURAL REGENERATION RESEARCH,2011,6. |
| APA | (2011).Brain-derived neurotrophic factor induces neuron-like cellular differentiation of mesenchymal stem cells derived from human umbilical cord blood cells in vitro.NEURAL REGENERATION RESEARCH,6. |
| MLA | "Brain-derived neurotrophic factor induces neuron-like cellular differentiation of mesenchymal stem cells derived from human umbilical cord blood cells in vitro".NEURAL REGENERATION RESEARCH 6(2011). |
入库方式： OAI收割
来源：合肥物质科学研究院
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