Antagonizing CDK8 Sensitizes Colorectal Cancer to Radiation Through Potentiating the Transcription of e2f1 Target Gene apaf1
文献类型：期刊论文
| 作者 | Chen, Bin1,2 ; Wen, Pengbo1,2; Hu, Guanshuo1,2; Gao, Yang1,2; Qi, Xiaojing1,2; Zhu, Kaili1,2; Chen, Shaopeng1; Wu, Lijun1; Xu, An1; Zhao, Guoping1
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| 刊名 | FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
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| 出版日期 | 2020-06-12 |
| 卷号 | 8 |
| ISSN号 | 2296-634X |
| 关键词 | CDK8 transcriptional regulation e2f1 apaf1 radiotherapy apoptosis |
| DOI | 10.3389/fcell.2020.00408 |
| 通讯作者 | Zhao, Guoping(gpz@ipp.ac.cn) |
| 英文摘要 | Radiotherapy is an essential curative treatment modality for colorectal cancer. Apoptosis is the major mechanism of IR-induced cell death and aberrant apoptotic signaling results in radioresistance, which is a hallmark of most, perhaps all, types of human cancers. Potentiating the induction of apoptosis is an emerging strategy for cancer radiotherapy. Here, we determined that targeting CDK8 selectively radiosensitized colorectal cancer through the mitochondria-dependent intrinsic apoptotic signaling, which was mediated through the induction of the transcription of apaf1 that was e2f1- and not p53-dependent. Importantly, the enhanced transcriptional activity of e2f1 was dependent on the kinase activity of CDK8 itself and not on the assembling of the mediator complex. In addition, clinical inhibitor, andin vivostudies confirmed the radiosensitizing effect of CDK8. Our results provide a new targeting strategy to improve the radiotherapy of CRC. |
| WOS关键词 | BETA-CATENIN ; KINASE ; POLYMERASE ; APOPTOSIS ; GAMMA-H2AX ; P53 ; SUBCOMPLEX ; ELONGATION ; ACTIVATION ; CLEAVAGE |
| 资助项目 | National Natural Science Foundation of China[31870845] ; National Natural Science Foundation of China[11835014] ; National Natural Science Foundation of China[31601124] ; CAS Pioneer Hundred Talents Program |
| WOS研究方向 | Cell Biology ; Developmental Biology |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000543829500001 |
| 资助机构 | National Natural Science Foundation of China ; CAS Pioneer Hundred Talents Program |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/43151]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhao, Guoping |
| 作者单位 | 1.Chinese Acad Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Anhui Prov Key Lab Environm Toxicol & Pollut Cont, Hefei Inst Phys Sci, Hefei, Peoples R China 2.Univ Sci & Technol China, Hefei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Bin,Wen, Pengbo,Hu, Guanshuo,et al. Antagonizing CDK8 Sensitizes Colorectal Cancer to Radiation Through Potentiating the Transcription of e2f1 Target Gene apaf1[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2020,8. |
| APA | Chen, Bin.,Wen, Pengbo.,Hu, Guanshuo.,Gao, Yang.,Qi, Xiaojing.,...&Zhao, Guoping.(2020).Antagonizing CDK8 Sensitizes Colorectal Cancer to Radiation Through Potentiating the Transcription of e2f1 Target Gene apaf1.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,8. |
| MLA | Chen, Bin,et al."Antagonizing CDK8 Sensitizes Colorectal Cancer to Radiation Through Potentiating the Transcription of e2f1 Target Gene apaf1".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 8(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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