Effects of exercise and diet interventions on obesity-related sleep disorders in men: study protocol for a randomized controlled trial
文献类型：期刊论文
| 作者 | Tan,Xiao1; Saarinen,Antti2; Mikkola,Tuija M1; Tenhunen,Jarkko1; Martinm?ki,Samu1; Rahikainen,Aki1; Cheng,Shumei1; Eklund,Niklas3; Pekkala,Satu1; Wiklund,Petri1 |
| 刊名 | Trials
 |
| 出版日期 | 2013-07-26 |
| 卷号 | 14 |
| 关键词 | Lifestyle intervention Sleep disorders Quality of sleep Obstructive sleep apnea Insomnia Sleep measurement Obesity Gut microbiota Neurotransmitters |
| ISSN号 | 1745-6215 |
| DOI | 10.1186/1745-6215-14-235 |
| 通讯作者 | Cheng,Sulin(sulin.cheng@jyu.fi) |
| 英文摘要 | AbstractBackgroundSleep is essential for normal and healthy living. Lack of good quality sleep affects physical, mental and emotional functions. Currently, the treatments of obesity-related sleep disorders focus more on suppressing sleep-related symptoms pharmaceutically and are often accompanied by side effects. Thus, there is urgent need for alternative ways to combat chronic sleep disorders. This study will investigate underlying mechanisms of the effects of exercise and diet intervention on obesity-related sleep disorders, the role of gut microbiota in relation to poor quality of sleep and day-time sleepiness, as well as the levels of hormones responsible for sleep-wake cycle regulation.Methods/designParticipants consist of 330 (target sample) Finnish men aged 30 to 65 years. Among them, we attempt to randomize 180 (target sample) with sleep disorders into exercise and diet intervention. After screening and physician examination, 101 men with sleep disorders are included and are randomly assigned into three groups: exercise (n = 33), diet (n = 35), and control (n = 33). In addition, we attempt to recruit a target number of 150 healthy men without sleep disorders as the reference group. The exercise group undergoes a six-month individualized progressive aerobic exercise program based on initial fitness level. The diet group follows a six month specific individualized diet program. The control group and reference group are asked to maintain their normal activity and diet during intervention. Measurements are taken before and after the intervention. Primary outcomes include objective sleep measurements by polysomnography and a home-based non-contact sleep monitoring system, and subjective sleep evaluation by questionnaires. Secondary outcome measures include anthropometry, body composition, fitness, sleep disorder-related lifestyle risk factors, composition of gut microbiota and adipose tissue metabolism, as well as specific hormone and neurotranmitter levels and inflammatory biomarkers from venous blood samples.DiscussionIt is expected that the improvement of sleep quality after exercise and diet intervention will be evident both in subjective and objective measures of quality of sleep. Additionally, the change of sleep quality induced by exercise and diet intervention is expected to be related to the changes in specific hormones and inflammatory biomarkers, and in the composition of gut microbiota.Trial registrationCurrent Controlled Trials ISRCTN77172005 |
| 语种 | 英语 |
| WOS记录号 | BMC:10.1186/1745-6215-14-235 |
| 出版者 | BioMed Central |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/42784]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Cheng,Sulin |
| 作者单位 | 1.University of Jyv?skyl?; Department of Health Sciences 2.Central Finland Health Care District; Central Finland Central Hospital 3.Vitalmed Research Center; Helsinki Sleep Clinic 4.University of Jyv?skyl?, (Agora); Department of Mathematical Information Technology 5.Chinese Academy of Sciences; Institute of Intelligent Machines 6.Oulu University Hospital; Department of Medical Rehabilitation 7.University of Oulu; Institute of Health Sciences |
| 推荐引用方式 GB/T 7714 | Tan,Xiao,Saarinen,Antti,Mikkola,Tuija M,et al. Effects of exercise and diet interventions on obesity-related sleep disorders in men: study protocol for a randomized controlled trial[J]. Trials,2013,14. |
| APA | Tan,Xiao.,Saarinen,Antti.,Mikkola,Tuija M.,Tenhunen,Jarkko.,Martinm?ki,Samu.,...&Cheng,Sulin.(2013).Effects of exercise and diet interventions on obesity-related sleep disorders in men: study protocol for a randomized controlled trial.Trials,14. |
| MLA | Tan,Xiao,et al."Effects of exercise and diet interventions on obesity-related sleep disorders in men: study protocol for a randomized controlled trial".Trials 14(2013). |
入库方式： OAI收割
来源：合肥物质科学研究院
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