Non-thermal plasma treatment altered gene expression profiling in non-small-cell lung cancer A549 cells
文献类型：期刊论文
| 作者 | Hou,Jue1; Ma,Jie1,2; Yu,K. N.1,4; Li,Wei1; Cheng,Cheng3; Bao,Lingzhi1,5; Han,Wei1,5
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| 刊名 | BMC Genomics
 |
| 出版日期 | 2015-06-06 |
| 卷号 | 16 |
| ISSN号 | 1471-2164 |
| 关键词 | Non-thermal plasma Gene profiling NSCLC A549 cell line Multiple signal pathways |
| DOI | 10.1186/s12864-015-1644-8 |
| 通讯作者 | Bao,Lingzhi(lingzhibao@hfcas.ac.cn) ; Han,Wei(hanw@hfcas.ac.cn) |
| 英文摘要 | AbstractBackgroundRecent technological advances in atmospheric plasmas have made the creation of non-thermal atmospheric pressure plasma (NTP) possible for utilization in the medical field. Although accumulated evidence suggests that NTP induces cell death in various cancer cell types thus offering a promising alternative treatment strategy, the mechanism underlying its therapeutic effect is not fully understood.ResultsWe analyzed relevant signaling cascades associated with the tumor protein p53, in particular the cell cycle arrest, DNA damage as well as the underlying apoptosis pathways. Based on our results, the major effect from plasma exposure was found to be the activation of MAPK and p53 signaling pathways, resulting in changes in gene expression of MEKK, GADD, FOS and JUN. Finally, a significant modulation in expression of genes related to cellular proliferation and differentiation was observed.ConclusionOverall, the presented data of the tumor transcriptome helped identify the key players in modulated gene expression following exposure to plasma at the molecular level, and also helped interpret the downstream processes. The present work laid the foundation for further studies to clarify the roles of multiple pathways in plasma-induced biological processes. Further investigation of these genes in other cell lines may reveal comprehensive mechanisms of plasma induced effects. |
| 语种 | 英语 |
| 出版者 | BioMed Central |
| WOS记录号 | BMC:10.1186/S12864-015-1644-8 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/42778]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Bao,Lingzhi; Han,Wei |
| 作者单位 | 1.Chinese Academy of Sciences; Center of Medical Physics and Technology, Hefei Institutes of Physical Science 2.University of Science and Technology of China; School of Life Sciences 3.Chinese Academy of Sciences; Institute of Plasma Physics, Hefei Institutes of Physical Sciences 4.City University of Hong Kong; Department of Physics and Materials Science 5. |
| 推荐引用方式 GB/T 7714 | Hou,Jue,Ma,Jie,Yu,K. N.,et al. Non-thermal plasma treatment altered gene expression profiling in non-small-cell lung cancer A549 cells[J]. BMC Genomics,2015,16. |
| APA | Hou,Jue.,Ma,Jie.,Yu,K. N..,Li,Wei.,Cheng,Cheng.,...&Han,Wei.(2015).Non-thermal plasma treatment altered gene expression profiling in non-small-cell lung cancer A549 cells.BMC Genomics,16. |
| MLA | Hou,Jue,et al."Non-thermal plasma treatment altered gene expression profiling in non-small-cell lung cancer A549 cells".BMC Genomics 16(2015). |
入库方式： OAI收割
来源：合肥物质科学研究院
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