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Interplay Between Receptor-Ligand Binding and Lipid Domain Formation Depends on the Mobility of Ligands in Cell-Substrate Adhesion

文献类型：期刊论文

作者Li, Long3,4; Wang, Xiaohuan2,3,4; Wu, Helong1; Shao, Yingfeng3,4; Wu, Huaping1; Song, Fan2,3,4; Song F(宋凡); Shao YF(邵颖峰); Li L(李龙)
刊名FRONTIERS IN MOLECULAR BIOSCIENCES
出版日期2021-04-12
卷号8页码:9
关键词cell adhesion receptor-ligand binding nanoscale lipid cluster ligand mobility phase separation binding constant
DOI10.3389/fmolb.2021.655662
通讯作者Shao, Yingfeng(shaoyf@lnm.imech.ac.cn) ; Wu, Huaping(wuhuaping@gmail.com) ; Song, Fan(songf@lnm.imech.ac.cn)
英文摘要Cell-cell adhesion and the adhesion of cells to extracellular matrix are mediated by the specific binding of receptors on the cell membrane to their cognate ligands on the opposing surface. The adhesion receptors can exhibit affinity for nanoscale lipid clusters that form in the cell membrane. Experimental studies of such adhesion systems often involve a cell adhering either to a solid surface with immobile ligands or a supported lipid bilayer with mobile ligands. A central question in these cell-substrate adhesions is how the mobility of the ligands physically affects their binding to the adhesion receptors and thereby the behavior of the nanoscale lipid clusters associated with the receptors. Using a statistical mechanical model and Monte Carlo simulations for the adhesion of cells to substrates with ligands, we find that, for mobile ligands, binding to adhesion receptors can promote the formation of mesoscale lipid domains, which in turn enhances the receptor-ligand binding. However, in the case of immobile ligands, the receptor-ligand binding and the tendency for the nanoscale lipid clusters to further coalesce depend on the distribution of the ligands on the substrate. Our findings help to explain why different adhesion experiments for identifying the interplay between receptor-ligand binding and heterogeneities in cell membranes led to contradictory results.
资助项目NSFC Basic Science Center Program for Multiscale Problems in Nonlinear Mechanics[11988102] ; Youth Innovation Promotion Association CAS ; National Natural Science Foundation of China[11902327] ; National Natural Science Foundation of China[11972041] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB22040102]
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:000643696100001
资助机构NSFC Basic Science Center Program for Multiscale Problems in Nonlinear Mechanics ; Youth Innovation Promotion Association CAS ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
源URL[http://dspace.imech.ac.cn/handle/311007/86500]  
专题力学研究所_非线性力学国家重点实验室
通讯作者Shao, Yingfeng; Wu, Huaping; Song, Fan
作者单位1.Zhejiang Univ Technol, Coll Mech Engn, Hangzhou, Peoples R China
2.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Beijing Key Lab Engn Construct & Mechanobiol, Inst Mech, Beijing, Peoples R China
4.Chinese Acad Sci, State Key Lab Nonlinear Mech LNM, Inst Mech, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Li, Long,Wang, Xiaohuan,Wu, Helong,et al. Interplay Between Receptor-Ligand Binding and Lipid Domain Formation Depends on the Mobility of Ligands in Cell-Substrate Adhesion[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2021,8:9.
APA Li, Long.,Wang, Xiaohuan.,Wu, Helong.,Shao, Yingfeng.,Wu, Huaping.,...&李龙.(2021).Interplay Between Receptor-Ligand Binding and Lipid Domain Formation Depends on the Mobility of Ligands in Cell-Substrate Adhesion.FRONTIERS IN MOLECULAR BIOSCIENCES,8,9.
MLA Li, Long,et al."Interplay Between Receptor-Ligand Binding and Lipid Domain Formation Depends on the Mobility of Ligands in Cell-Substrate Adhesion".FRONTIERS IN MOLECULAR BIOSCIENCES 8(2021):9.

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来源：力学研究所

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