Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli
文献类型：期刊论文
| 作者 | Shu XY(舒芯钰)1,2,3; Li N(李宁)1,2,3 ; Wu Y(武亿)1,2,3; Li W(李旺)1,2,3; Zhang XY(张晓宇)1,2,3; Li PW(李培文)2,3; Lv DY(吕东媛)1,2,3; Lv SQ(吕守芹)1,2,3; Long M(龙勉)1,2,3
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| 刊名 | ACTA MECHANICA SINICA
 |
| 出版日期 | 2021-03-10 |
| 页码 | 17 |
| 关键词 | Liver sinusoidal endothelial cell Shear stress Mechanical stretch Extracellular matrix Stiffness |
| ISSN号 | 0567-7718 |
| DOI | 10.1007/s10409-021-01057-3 |
| 通讯作者 | Li, Ning(lining_1@imech.ac.cn) ; Long, Mian(mlong@imech.ac.cn) |
| 英文摘要 | Liver sinusoidal endothelial cells (LSECs) are the gatekeeper of liver to maintain hepatic homeostasis. They are formed into the highly specialized endothelium between vascular lumen and the space of Disse and are mechanosensitive to respond varied microenvironments. Shear stress and mechanical stretch induced by blood perfusion and substrate stiffness enhancement derived from deposition of extracellular matrix (ECM) are major mechanical stimuli that surround LSECs. This review introduces how LSECs respond to the external forces in both physiological and pathological cases and what is the interplay of LSECs with other hepatic cells. Molecular mechanisms that potentiate LSECs mechanotransduction are also discussed. |
| 分类号 | 二类 |
| 资助项目 | National Natural Science Foundation of China[91642203] ; National Natural Science Foundation of China[31627804] ; National Natural Science Foundation of China[31870930] ; Scientific Instrument Developing Project ; Strategic Priority Research Program ; Frontier Science Key Project of Chinese Academy of Sciences[GJJSTU20190005] ; Frontier Science Key Project of Chinese Academy of Sciences[QYZDJ-SSW-JSC018] ; Frontier Science Key Project of Chinese Academy of Sciences[XDB22040101] |
| WOS研究方向 | Engineering ; Mechanics |
| 语种 | 英语 |
| WOS记录号 | WOS:000627222700002 |
| 资助机构 | National Natural Science Foundation of China ; Scientific Instrument Developing Project ; Strategic Priority Research Program ; Frontier Science Key Project of Chinese Academy of Sciences |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/86293]  |
| 专题 | 力学研究所_国家微重力实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China; 3.Chinese Acad Sci, Ctr Biomech & Bioengn, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Shu XY,Li N,Wu Y,et al. Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli[J]. ACTA MECHANICA SINICA,2021:17. |
| APA | 舒芯钰.,李宁.,武亿.,李旺.,张晓宇.,...&龙勉.(2021).Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli.ACTA MECHANICA SINICA,17. |
| MLA | 舒芯钰,et al."Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli".ACTA MECHANICA SINICA (2021):17. |
入库方式： OAI收割
来源：力学研究所
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