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Intratracheally instillated diesel PM2.5 significantly altered the structure and composition of indigenous murine gut microbiota

文献类型：期刊论文

作者Liu, Ying1,3,4; Wang, Tong1,3,4; Si, Bo1,4; Du, Hua1,4; Liu, Yun1,4; Waqas, Ahmed1,4; Huang, Shengwei1,4; Zhao, Guoping1,4; Chen, Shaopeng1,4; Xu, An1,2,4
刊名ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
出版日期2021-03-01
卷号210
关键词Diesel PM2.5 Intratracheal instillation Gut microbiota Structure Composition
ISSN号0147-6513
DOI10.1016/j.ecoenv.2021.111903
通讯作者Xu, An(anxu@ipp.ac.cu)
英文摘要A diverse and large community of gut microbiota reside in the intestinal tract of various organisms and play important roles in metabolism and immune homeostasis of its host. The disorders of microbiota-host interaction have been closely associated with numerous chronic inflammatory and metabolic diseases, including inflammatory bowel disease and type 2 diabetes. The accumulating evidence has shown that fine particulate matter (PM2.5) exposure contributes to the diabetes, atherosclerosis and inflammatory bowel diseases; however, few studies have explored the impact of inhaled diesel PM2.5 on gut microbiota in vivo. In this study, C57BL/6J mice were exposed to diesel PM2.5 for 14 days via intratracheal instillation, and colon tissues and feces were harvested for microbiota analysis. Using high-throughput sequencing technology, we observed that intratracheally instillated diesel PM2.5 significantly altered the gut microbiota diversity and community. At the phylum and genus levels, principal coordinate analysis (PCoA) and principal component analysis (PCA) indicated pronounced segregation of microbiota compositions, which were further confirmed by beta diversity analysis. As the most affected phylum, Bacteroidetes was greatly diminished by diesel PM2.5. On the genus level, Escherichia, Parabacteroides, Akkermansia, and Oscillibacter were significantly elevated by diesel PM2.5 exposure. Our findings provided clear evidence that exposure to diesel PM2.5 via intratracheal instillation deteriorated the gastrointestinal (GI) tract and significantly altered the structure and composition of gut microbiota, which might subsequently contribute to the developmental abnormalities of inflammation, immunity and metabolism.
资助项目National Natural Science Foundation of China[91743106]
WOS研究方向Environmental Sciences & Ecology ; Toxicology
语种英语
WOS记录号WOS:000611820900001
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
资助机构National Natural Science Foundation of China
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/120179]  
专题中国科学院合肥物质科学研究院
通讯作者Xu, An
作者单位1.Chinese Acad Sci, Anhui Prov Key Lab Environm Toxicol & Pollut Cont, High Field Magnet Lab, Hefei Inst Phys Sci, Hefei 230031, Anhui, Peoples R China
2.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Anhui, Peoples R China
3.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China
4.Chinese Acad Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Ying,Wang, Tong,Si, Bo,et al. Intratracheally instillated diesel PM2.5 significantly altered the structure and composition of indigenous murine gut microbiota[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2021,210.
APA Liu, Ying.,Wang, Tong.,Si, Bo.,Du, Hua.,Liu, Yun.,...&Xu, An.(2021).Intratracheally instillated diesel PM2.5 significantly altered the structure and composition of indigenous murine gut microbiota.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,210.
MLA Liu, Ying,et al."Intratracheally instillated diesel PM2.5 significantly altered the structure and composition of indigenous murine gut microbiota".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 210(2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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