中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
XXYLT1 methylation contributes to the occurrence of lung adenocarcinoma Methylation and lung adenocarcinoma

文献类型:期刊论文

作者Zeng, Hui2,3,4; Wang, Ying1; Wang, Ying2,3,4; Zhang, Yongjun2,3,4
刊名MEDICINE
出版日期2021-01-08
卷号100
关键词Lung adenocarcinoma DNA methylation gene expression XXYLT1
ISSN号0025-7974
DOI10.1097/MD.0000000000024150
通讯作者Zhang, Yongjun(zhangyj@zjcc.org.cn)
英文摘要Background: There is evidence that DNA methylation play major roles in lung cancer. In our previously study, C3 or f21 , also referred to as XXYLT1, rs2131877 polymorphism is associated with a reduced risk of lung adenocarcinoma. So, we explored the role of XXYLT1 methylation in lung adenocarcinoma. Methods: This study was conducted in 2 steps. In the first step, we recruited 15 patients with lung adenocarcinoma. Cancer tissues and para-carcinoma tissues were obtained from each of the patients. In the second step, 150 patients with lung adenocarcinom were enrolled, and cancer and normal lung tissue were obtained from each patients, respectively. The expression levels of XXYLT1 mRNA were determined, the deoxyribonucleic acid methylation status was analyzed by MassARRAY Spectrometry. The methylation data of individual units were generated by EpiTyper v1.0.5 software. Results: The XXYLT1 mRNA expression was significantly lower in cancer tissues than in para-carcinoma and normal lung tissues. Meanwhile, the methylation rates of three CpG units (CpG_23, CpG_25, and CpG_60.61.62.63.64.65) within the XXYLT1 gene were higher in cancer tissues compared to the para-carcinoma and the normal lung tissues. This difference was particularly significant in male patients. Conclusions: Our results suggested that methylation of XXYLT1 may have significance in the pathogenesis of lung adenocarcinoma.
资助项目Zhejiang Provincial Medical and Health Scientific and Technical Foundation[2019KY043] ; Zhejiang Provincial Medical and Health Scientific and Technical Foundation[2020KY470]
WOS研究方向General & Internal Medicine
语种英语
WOS记录号WOS:000612794500071
出版者LIPPINCOTT WILLIAMS & WILKINS
资助机构Zhejiang Provincial Medical and Health Scientific and Technical Foundation
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/120194]  
专题中国科学院合肥物质科学研究院
通讯作者Zhang, Yongjun
作者单位1.Zhejiang Chinese Med Univ, Dept Basic Med Sci, Hangzhou, Peoples R China
2.Chinese Acad Sci, Inst Canc Res & Basic Med Sci, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Canc Hosp, Beijing, Peoples R China
4.Zhejiang Canc Hosp, Hangzhou, Peoples R China
推荐引用方式
GB/T 7714
Zeng, Hui,Wang, Ying,Wang, Ying,et al. XXYLT1 methylation contributes to the occurrence of lung adenocarcinoma Methylation and lung adenocarcinoma[J]. MEDICINE,2021,100.
APA Zeng, Hui,Wang, Ying,Wang, Ying,&Zhang, Yongjun.(2021).XXYLT1 methylation contributes to the occurrence of lung adenocarcinoma Methylation and lung adenocarcinoma.MEDICINE,100.
MLA Zeng, Hui,et al."XXYLT1 methylation contributes to the occurrence of lung adenocarcinoma Methylation and lung adenocarcinoma".MEDICINE 100(2021).

入库方式: OAI收割

来源:合肥物质科学研究院

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