DNA hydrogel-based gene editing and drug delivery systems
文献类型：期刊论文
| 作者 | Mo, Fangli1; Jiang, Kai1; Zhao, Di1; Wang, Yuqi1; Song, Jie1,2; Tan, Weihong2 |
| 刊名 | ADVANCED DRUG DELIVERY REVIEWS
 |
| 出版日期 | 2021 |
| 卷号 | 168 |
| 关键词 | DNA hydrogels Stimuli responsiveness Drug delivery Biomacromolecules Gene therapy |
| ISSN号 | 0169-409X |
| DOI | 10.1016/j.addr.2020.07.018 |
| 通讯作者 | Song, Jie(sjie@sjtu.edu.cn) ; Tan, Weihong(tan@hnu.edu.cn) |
| 英文摘要 | Deoxyribonucleic acid (DNA) is a promising synthesizer for precisely constructing almost arbitrary geometry in two and three dimensions. Among various DNA-based soft materials, DNA hydrogels are comprised of hydrophilic polymeric networks of crosslinked DNA chains. For their properties of biocompatibility, porosity, sequence programmability and tunable multifunctionality, DNA hydrogels have been widely studied in bioanalysis and biomedicine. In this review, recent developments in DNA hydrogels and their applications in drug delivery systems are highlighted. First, physical and chemical crosslinking methods for constructing DNA hydrogels are introduced. Subsequently, responses of DNA hydrogels to nonbiological and biological stimuli are described. Finally, DNA hydrogel-based delivery platforms for different types of drugs are detailed. With the emergence of gene therapy, this review also gives future prospects for combining DNA hydrogels with the gene editing toolbox. (c) 2020 Elsevier B.V. All rights reserved. |
| WOS关键词 | APTAMER-FUNCTIONALIZED HYDROGEL ; CROSS-LINKED HYDROGEL ; ACUTE KIDNEY INJURY ; QUANTUM DOTS ; RNA INTERFERENCE ; BIOMEDICAL APPLICATIONS ; RESPONSIVE HYDROGELS ; EFFICIENT DELIVERY ; CO-DELIVERY ; IN-VITRO |
| 资助项目 | National Natural Science Foundation of China[81822024] ; National Natural Science Foundation of China[11761141006] ; National Natural Science Foundation of China[21605102] ; National Key Research and Development Program of China[2017YFC1200904] ; Natural Science Foundation of Shanghai[19520714100] ; Natural Science Foundation of Shanghai[19ZR1475800] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000612867300005 |
| 出版者 | ELSEVIER |
| 资助机构 | National Natural Science Foundation of China ; National Key Research and Development Program of China ; Natural Science Foundation of Shanghai |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/120288]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Song, Jie; Tan, Weihong |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Inst Nano Biomed & Engn, Sch Elect Informat & Elect Engn, Dept Instrument Sci & Engn, Shanghai 200240, Peoples R China 2.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Canc & Basic Med IBMC, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mo, Fangli,Jiang, Kai,Zhao, Di,et al. DNA hydrogel-based gene editing and drug delivery systems[J]. ADVANCED DRUG DELIVERY REVIEWS,2021,168. |
| APA | Mo, Fangli,Jiang, Kai,Zhao, Di,Wang, Yuqi,Song, Jie,&Tan, Weihong.(2021).DNA hydrogel-based gene editing and drug delivery systems.ADVANCED DRUG DELIVERY REVIEWS,168. |
| MLA | Mo, Fangli,et al."DNA hydrogel-based gene editing and drug delivery systems".ADVANCED DRUG DELIVERY REVIEWS 168(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。