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Identification of FPR3 as a Unique Biomarker for Targeted Therapy in the Immune Microenvironment of Breast Cancer

文献类型：期刊论文

作者Qi, Jian2,3,4; Liu, Yu2,3,4; Hu, Jiliang5; Lu, Li1; Dou, Zhen6; Dai, Haiming2,4; Wang, Hongzhi2,4; Yang, Wulin2,4
刊名FRONTIERS IN PHARMACOLOGY
出版日期2021-02-11
卷号11
关键词breast cancer immune microenvironment ESTIMATE algorithm immune checkpoint FPR3
ISSN号1663-9812
DOI10.3389/fphar.2020.593247
通讯作者Wang, Hongzhi(yangw@cmpt.ac.cn) ; Yang, Wulin(wanghz@hfcas.ac.cn)
英文摘要Although research into immunotherapy is growing, its use in the treatment of breast cancer remains limited. Thus, identification and evaluation of prognostic biomarkers of tissue microenvironments will reveal new immune-based therapeutic strategies for breast cancer. Using an in silico bioinformatic approach, we investigated the tumor microenvironmental and genetic factors related to breast cancer. We calculated the Immune score, Stromal score, Estimate score, Tumor purity, TMB (Tumor mutation burden), and MATH (Mutant-allele tumor heterogeneity) of Breast cancer patients from the Cancer Genome Atlas (TCGA) using the ESTIMATE algorithm and Maftools. Significant correlations between Immune/Stromal scores with breast cancer subtypes and tumor stages were established. Importantly, we found that the Immune score, but not the Stromal score, was significantly related to the patient's prognosis. Weighted correlation network analysis (WGCNA) identified a pattern of gene function associated with Immune score, and that almost all of these genes (388 genes) are significantly upregulated in the higher Immune score group. Protein-protein interaction (PPI) network analysis revealed the enrichment of immune checkpoint genes, predicting a good prognosis for breast cancer. Among all the upregulated genes, FPR3, a G protein-coupled receptor essential for neutrophil activation, is the sole factor that predicts poor prognosis. Gene set enrichment analysis analysis showed FRP3 upregulation synergizes with the activation of many pathways involved in carcinogenesis. In summary, this study identified FPR3 as a key immune-related biomarker predicting a poor prognosis for breast cancer, revealing it as a promising intervention target for immunotherapy.
资助项目National Natural Science Foundation of China[81872276] ; Shanxi Scholarship Council of China[2020085] ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology[2018CXFX006] ; foundation of Anhui Province Key Laboratory of Medical Physics and Technology[LMPT201908]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000621359300001
出版者FRONTIERS MEDIA SA
资助机构National Natural Science Foundation of China ; Shanxi Scholarship Council of China ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; foundation of Anhui Province Key Laboratory of Medical Physics and Technology
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/120291]  
专题中国科学院合肥物质科学研究院
通讯作者Wang, Hongzhi; Yang, Wulin
作者单位1.Shanxi Med Univ, Dept Anat, Taiyuan, Peoples R China
2.Chinese Acad Sci, Anhui Prov Key Lab Med Phys & Technol, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Hefei, Peoples R China
3.Grad Sch USTC, Sci Isl Branch, Hefei, Peoples R China
4.Chinese Acad Sci, Hefei Canc Hosp, Hefei, Peoples R China
5.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Neurosurg, Shenzhen, Peoples R China
6.Univ Sci & Technol China, Hefei Natl Sci Ctr Phys Sci Microscale, Hefei, Peoples R China
推荐引用方式
GB/T 7714		 Qi, Jian,Liu, Yu,Hu, Jiliang,et al. Identification of FPR3 as a Unique Biomarker for Targeted Therapy in the Immune Microenvironment of Breast Cancer[J]. FRONTIERS IN PHARMACOLOGY,2021,11.
APA Qi, Jian.,Liu, Yu.,Hu, Jiliang.,Lu, Li.,Dou, Zhen.,...&Yang, Wulin.(2021).Identification of FPR3 as a Unique Biomarker for Targeted Therapy in the Immune Microenvironment of Breast Cancer.FRONTIERS IN PHARMACOLOGY,11.
MLA Qi, Jian,et al."Identification of FPR3 as a Unique Biomarker for Targeted Therapy in the Immune Microenvironment of Breast Cancer".FRONTIERS IN PHARMACOLOGY 11(2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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