NCK1-AS1 promotes the progression of lung squamous cell carcinoma through transcriptionally upregulating NCK1 via interacting with MYC
文献类型：期刊论文
| 作者 | Zhou, Xia1; Bao, Wuan2; Zhang, Danhong1; Yang, Yang2; Du, Xianghui1; Qiu, Guoqin1 |
| 刊名 | CANCER BIOLOGY & THERAPY
 |
| 出版日期 | 2021-02-26 |
| ISSN号 | 1538-4047 |
| 关键词 | NCK1-AS1 NCK1 LUSC MYC |
| DOI | 10.1080/15384047.2020.1842717 |
| 通讯作者 | Zhou, Xia(1154389861@qq.com) |
| 英文摘要 | Lung squamous cell carcinoma (LUSC) is a prevalent subtype of nonsmall cell lung cancer (NSCLC). Dysregulated long noncoding RNAs (lncRNAs) are increasingly identified as pivotal modulators in cancer progression. NCK1 divergent transcript (NCK1-AS1) is a lncRNA that has been proven to be oncogenic in different types of human cancers. However, whether it exerts similar functions in LUSC remains to be elusive. The present study focused on investigating the influence of NCK1-AS1 on the cellular process in LUSC and exploring its underlying mechanism. Through online bioinformatics analysis, we obtained a high NCK1-AS1 level in LUSC tissues. Meanwhile, we confirmed that NCK1-AS1 was upregulated in LUSC cells. Gain- or loss-of-function assays suggested that NCK1-AS1 prompted cell proliferation and migration, whilst impeded cell apoptosis in LUSC. Mechanistically, we revealed that NCK1-AS1 induced the upregulation of its nearby gene NCK adaptor protein 1 (NCK1) at the transcriptional level by interacting with the transcription factor MYC proto-oncogene (MYC). Rescue assays indicated that NCK1 participated in the regulation of NCK1-AS1 on LUSC progression. In conclusion, we firstly demonstrated the oncogenic role of NCK1-AS1 in LUSC and illustrated its downstream molecular mechanism. |
| 资助项目 | National Natural Science Foundation of China[81702968] ; Zhejiang Provincial Medicinal Health Program[2020KY469] ; Science and Technology Program of Traditional Chinese medicine in Zhejiang Province[2020ZA021] ; Science and Technology Program of Traditional Chinese medicine in Zhejiang Province[2021ZA022] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | TAYLOR & FRANCIS INC |
| WOS记录号 | WOS:000621678100001 |
| 资助机构 | National Natural Science Foundation of China ; Zhejiang Provincial Medicinal Health Program ; Science and Technology Program of Traditional Chinese medicine in Zhejiang Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/120490]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhou, Xia |
| 作者单位 | 1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Thorac Radiotherapy, Hangzhou, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Xia,Bao, Wuan,Zhang, Danhong,et al. NCK1-AS1 promotes the progression of lung squamous cell carcinoma through transcriptionally upregulating NCK1 via interacting with MYC[J]. CANCER BIOLOGY & THERAPY,2021. |
| APA | Zhou, Xia,Bao, Wuan,Zhang, Danhong,Yang, Yang,Du, Xianghui,&Qiu, Guoqin.(2021).NCK1-AS1 promotes the progression of lung squamous cell carcinoma through transcriptionally upregulating NCK1 via interacting with MYC.CANCER BIOLOGY & THERAPY. |
| MLA | Zhou, Xia,et al."NCK1-AS1 promotes the progression of lung squamous cell carcinoma through transcriptionally upregulating NCK1 via interacting with MYC".CANCER BIOLOGY & THERAPY (2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。