Multi-scale simulation of early kidney branching morphogenesis
文献类型：期刊论文
| 作者 | Cai, Wenran1; Wang, Yunqi2,3; Zhang, Jicong2,3; Zhang, Hong4; Luo, Tianzhi1 |
| 刊名 | PHYSICAL BIOLOGY
 |
| 出版日期 | 2021-03-01 |
| 卷号 | 18 |
| 关键词 | branch morphogenesis kidney development repulsion random work dihedral angle |
| ISSN号 | 1478-3967 |
| DOI | 10.1088/1478-3975/abd844 |
| 通讯作者 | Luo, Tianzhi(tzluo@ustc.edu.cn) |
| 英文摘要 | An important feature of the branch morphogenesis during kidney development is the termination of the tips on the outer surface of a kidney. This feature requires the avoidance of the intersection between the tips and existing ducts inside the kidney. Here, we started from a continuous model and implemented the coarse grained rules into a fast and discrete simulations. The ligand-receptor-based Turing mechanism suggests a repulsion that decreases exponentially with distance between interacting branches, preventing the intersection between neighboring branches. We considered this repulsive effect in numerical simulations and successfully reproduce the key features of the experimentally observed branch morphology for an E15.5 kidney. We examine the similarity of several geometrical parameters between the simulation results and experimental observations. The good agreement between the simulations and experiments suggests that the concentration decay caused by the absorption of glial cell line derived neurotrophic factor might be the key factor to affect the geometry in early kidney development. |
| 资助项目 | National Science Foundation of China[11572316] ; National Science Foundation of China[21777165] ; Fundamental Research Funds for the Central Universities[WK2480000006] ; Anhui Province Science and Technology Major Project[201903a07020019] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000621501100001 |
| 出版者 | IOP PUBLISHING LTD |
| 资助机构 | National Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Anhui Province Science and Technology Major Project |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/120634]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Luo, Tianzhi |
| 作者单位 | 1.Univ Sci & Technol China, Dept Modern Mech, CAS Key Lab Mech Behav & Design Mat, Hefei, Peoples R China 2.Beihang Univ, Sch Biol Sci & Med Engn, Beijing, Peoples R China 3.Beihang Univ, Hefei Innovat Res Inst, Hefei, Peoples R China 4.Chinese Acad Sci, Hefei Inst Phys Sci, Shushanhu Rd 350, Hefei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cai, Wenran,Wang, Yunqi,Zhang, Jicong,et al. Multi-scale simulation of early kidney branching morphogenesis[J]. PHYSICAL BIOLOGY,2021,18. |
| APA | Cai, Wenran,Wang, Yunqi,Zhang, Jicong,Zhang, Hong,&Luo, Tianzhi.(2021).Multi-scale simulation of early kidney branching morphogenesis.PHYSICAL BIOLOGY,18. |
| MLA | Cai, Wenran,et al."Multi-scale simulation of early kidney branching morphogenesis".PHYSICAL BIOLOGY 18(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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