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A Cascade Signaling Network between Artificial Cells Switching Activity of Synthetic Transmembrane Channels

文献类型：期刊论文

作者Yang, Qiuxia1; Guo, Zhenzhen1; Liu, Hui2; Peng, Ruizi1; Xu, Liujun1; Bi, Cheng1; He, Yaqing1; Liu, Qiaoling1; Tan, Weihong1,3,4,5
刊名JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
出版日期2021-01-13
卷号143
ISSN号0002-7863
DOI10.1021/jacs.0c09558
通讯作者Liu, Qiaoling(qlliu@iccas.ac.cn) ; Tan, Weihong(tan@hnu.edu.cn)
英文摘要Cell-cell communication plays a vital role in biological activities; in particular, membrane-protein interactions are profoundly significant. In order to explore the underlying mechanism of intercellular signaling pathways, a full range of artificial systems have been explored. However, many of them are complicated and uncontrollable. Herein we designed an artificial signal transduction system able to control the influx of environmental ions by triggering the activation of synthetic transmembrane channels immobilized on giant membrane vesicles (GMVs). A membrane protein-like stimulator from one GMV community (GMV(B)) stimulates a receptor on another GMV community (GMV(A)) to release ssDNA messengers, resulting in the activation of synthetic transmembrane channels to enable the influx of ions. This event, in turn, triggers signal responses encapsulated in the GMV(A) protocell model. By mimicking natural signal transduction pathways, this novel prototype provides a workable tool for investigating cell-cell communication and expands biological signaling systems in general as well as explores useful platforms for addressing scientific problems which involve materials science, chemistry, and medicine.
WOS关键词COMMUNICATION
资助项目NSFC[21827811] ; NSFC[21521063] ; Science and Technology Project of Hunan Province[2017DK2011] ; Postdoctoral Program for Innovative Talents of China[BX20190111]
WOS研究方向Chemistry
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000611083700032
资助机构NSFC ; Science and Technology Project of Hunan Province ; Postdoctoral Program for Innovative Talents of China
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/120649]  
专题中国科学院合肥物质科学研究院
通讯作者Liu, Qiaoling; Tan, Weihong
作者单位1.Hunan Univ, Coll Chem & Chem Engn, Aptamer Engn Ctr Hunan Prov,State Key Lab Chemo B, Coll Biol,Mol Sci & Biomed Lab MBL, Changsha 410082, Hunan, Peoples R China
2.Wuhan Univ, Coll Chem & Mol Sci, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Peoples R China
3.Shanghai Jiao Tong Univ, Inst Mol Med IMM, Renji Hosp, Shanghai Jiao Tong Univ Sch Med, Shanghai 200240, Peoples R China
4.Shanghai Jiao Tong Univ, Coll Chem & Chem Engn, Shanghai 200240, Peoples R China
5.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Canc & Basic Med IBMC, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Qiuxia,Guo, Zhenzhen,Liu, Hui,et al. A Cascade Signaling Network between Artificial Cells Switching Activity of Synthetic Transmembrane Channels[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2021,143.
APA Yang, Qiuxia.,Guo, Zhenzhen.,Liu, Hui.,Peng, Ruizi.,Xu, Liujun.,...&Tan, Weihong.(2021).A Cascade Signaling Network between Artificial Cells Switching Activity of Synthetic Transmembrane Channels.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,143.
MLA Yang, Qiuxia,et al."A Cascade Signaling Network between Artificial Cells Switching Activity of Synthetic Transmembrane Channels".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 143(2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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