Pan-cancer analyses demonstrate that ANKRD6 is associated with a poor prognosis and correlates with M2 macrophage infiltration in colon cancer
文献类型：期刊论文
| 作者 | Bai, Rui2,3; Wu, Dehao2; Shi, Zhong4; Hu, Wangxiong2; Li, Juan1; Chen, Yuanyuan1; Ge, Weiting2; Yuan, Ying2,3; Zheng, Shu2 |
| 刊名 | CHINESE JOURNAL OF CANCER RESEARCH
 |
| 出版日期 | 2021-02-01 |
| 卷号 | 33 |
| 关键词 | ANKRD6 colon cancer pan-cancer prognosis tumor-infiltrating |
| ISSN号 | 1000-9604 |
| DOI | 10.21147/j.issn.1000-9604.2021.01.10 |
| 通讯作者 | Yuan, Ying(yuanying1999@zju.edu.cn) ; Zheng, Shu(zhengshu@zju.edu.cn) |
| 英文摘要 | Objective. Ankyrin repeat domain-containing protein 6 (ANKRD6) is an ankyrin repeat-containing protein which is structurally related to vertebrate inversin and Drosophila Diego. However, the correlations between ANKRD6 and tumor-infiltrating immune cells in cancers is not clear. Methods: ANKRD6 expression was analyzed by Oncomine, Tumor Immune Estimation Resource (TIMER) and Gene Expression Profiling Interactive Analysis (GEPIA). PrognoScan and GEPIA were used to evaluate the influence of ANKRD6 on clinical prognosis. TIMER and CIBERSORT were used to analyze correlations between ANKRD6 expression levels and tumor immune cell infiltrates. Immunohistochemical analysis of the relationship between ANKRD6 expression and overall survival, as well as the relationship between ANKRD6 expression and M2 macrophage infiltration, was performed. Results: High level of ANKRD6 expression was associated with poor prognosis of colon cancer. ANKRD6 expression level was positively correlated with infiltrating levels of CD8+ T cells, CD4+ T cells, macrophages, neutrophils and dendritic cells in colon cancer by using TIMER. Using CIBERSORT, we found that in plasma cells, CD8+ T cells, CD4+ memory resting T cells, follicular helper T cells and activated natural killer cells were significantly lower in the ANKRD6-high group than in the ANKRD6-low group. M0 and M2 macrophages were significantly higher in the ANKRD6-high group than in the ANKRD6-low group. Immunohistochemistry confirmed that M2 macrophage infiltration in the ANKRD6-high group significantly increased. Conclusions: The high ANKRD6 expression is associated with poor prognosis of colon cancer. ANKRD6 expression is positively correlated with M2 macrophage infiltration in colon cancer. |
| WOS关键词 | WEB SERVER ; WNT ; PATHWAYS ; DIVERSIN |
| 资助项目 | Zhejiang Basic Public Welfare Research Project[LGF18H160040] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000623402500010 |
| 出版者 | CHINESE JOURNAL CANCER RESEARCH CO |
| 资助机构 | Zhejiang Basic Public Welfare Research Project |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/120825]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Yuan, Ying; Zheng, Shu |
| 作者单位 | 1.Hangzhou Canc Hosp, Dept Radiat Oncol, Hangzhou 310002, Peoples R China 2.Zhejiang Univ, Key Lab Canc Prevent & Intervent, Affiliated Hosp 2, Canc Inst,Minist Educ,Sch Med, Hangzhou 310009, Peoples R China 3.Zhejiang Univ, Key Lab Canc Prevent & Intervent, Affiliated Hosp 2, Dept Med Oncol,Minist Educ,Sch Med, Hangzhou 310009, Peoples R China 4.Chinese Acad Sci, Univ Chinese Acad Sci, Inst Canc & Basic Med ICBM, Dept Med Oncol,Canc Hosp, Hangzhou 310022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, Rui,Wu, Dehao,Shi, Zhong,et al. Pan-cancer analyses demonstrate that ANKRD6 is associated with a poor prognosis and correlates with M2 macrophage infiltration in colon cancer[J]. CHINESE JOURNAL OF CANCER RESEARCH,2021,33. |
| APA | Bai, Rui.,Wu, Dehao.,Shi, Zhong.,Hu, Wangxiong.,Li, Juan.,...&Zheng, Shu.(2021).Pan-cancer analyses demonstrate that ANKRD6 is associated with a poor prognosis and correlates with M2 macrophage infiltration in colon cancer.CHINESE JOURNAL OF CANCER RESEARCH,33. |
| MLA | Bai, Rui,et al."Pan-cancer analyses demonstrate that ANKRD6 is associated with a poor prognosis and correlates with M2 macrophage infiltration in colon cancer".CHINESE JOURNAL OF CANCER RESEARCH 33(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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