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Phospho-regulation and function of ULK1-ATG13 during the cell cycle

文献类型：期刊论文

作者Li, Zhiyuan1,2; Zhang, Xin1,3
刊名AUTOPHAGY
出版日期2021-03-19
关键词ULK1 ATG13 CDK1 autophagy mitosis
ISSN号1554-8627
DOI10.1080/15548627.2021.1898750
通讯作者Zhang, Xin(xinzhang@hmfl.ac.cn)
英文摘要Although it has been reported that some autophagy-related proteins could regulate the cell cycle, the function of ULK1-ATG13, the only protein kinase complex in macroautophagy/autophagy, remains unclear. We recently found that mitotic ULK1 and ATG13 are both substrates of the key cell cycle regulator CDK1-CCNB/cyclin B. CDK1-induced ULK1-ATG13 phosphorylation promotes mitotic autophagy and cell cycle progression. Moreover, ULK1 and ATG13 double-knockout significantly inhibits cell cycle progression and tumor cell proliferation in vitro and in vivo. These findings bridge the mutual regulation between autophagic and mitotic key kinases and provide a theoretical basis for autophagy- and cell division-related diseases based on combination therapy.
资助项目National Key Research and Development Program of China[2016YFA0400900] ; CASHIPS Director's Fund[YZJJ2019QN17] ; Anhui Natural Science Foundation[1908085MC88] ; National Natural Science Foundation of China[31900508]
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:000629818200001
出版者TAYLOR & FRANCIS INC
资助机构National Key Research and Development Program of China ; CASHIPS Director's Fund ; Anhui Natural Science Foundation ; National Natural Science Foundation of China
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/120862]  
专题中国科学院合肥物质科学研究院
通讯作者Zhang, Xin
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, High Magnet Field Lab, Hefei, Peoples R China
2.Univ Dundee, Med Res Council, Prot Phosphorylat & Ubiquitylat Unit, Sch Life Sci, Dundee, Scotland
3.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei, Peoples R China
推荐引用方式
GB/T 7714		 Li, Zhiyuan,Zhang, Xin. Phospho-regulation and function of ULK1-ATG13 during the cell cycle[J]. AUTOPHAGY,2021.
APA Li, Zhiyuan,&Zhang, Xin.(2021).Phospho-regulation and function of ULK1-ATG13 during the cell cycle.AUTOPHAGY.
MLA Li, Zhiyuan,et al."Phospho-regulation and function of ULK1-ATG13 during the cell cycle".AUTOPHAGY (2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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