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Quantitative definitions of pain, CA19-9, and tumor size as high-risk features of resectable pancreatic cancer: a single-center retrospective cohort study

文献类型：期刊论文

作者Xu, Dongni1; Wang, Jiangling3; Liu, Ting1; Huang, Zhuoshan2; Luo, Jianwei1; Chen, Yuqing1; Lu, Yanan1
刊名GLAND SURGERY
出版日期2021-02-01
卷号10
关键词Resectable pancreatic cancer carbohydrate antigen 19-9 (CA19-9) abdominal and/or back pain primary tumor size lymph node metastasis prognosis pancreatitis
ISSN号2227-684X
DOI10.21037/gs-20-877
通讯作者Chen, Yuqing(chenyq97@mail.sysu.edu.cn) ; Lu, Yanan(luynan@mail.sysu.edu.cn)
英文摘要Background: Pancreatic ductal adenocarcinoma (PDAC) is one of malignant tumors with the worst prognosis. Surgery and adjuvant chemotherapy are the main treatments for resectable pancreatic cancer. For borderline resectable PDAC, neoadjuvant chemotherapy has been advised. For clearly resectable PDAC, neoadjuvant chemotherapy also might be considered for the patients with high-risk features, but with no precise quantitative criteria to define these features. So, this study aimed to re-evaluate the relationship between high-risk features and prognosis of clearly resectable pancreatic cancer, and to define the precise criteria for these high-risk features. Methods: Data from 211 patients with clearly resectable pancreatic cancer were reviewed to assess the relationship between overall survival (OS) after surgery and high-risk features, and cut-off values were determined for high-risk features that were associated with poor prognosis of clearly resectable pancreatic cancer. Results: Lymph node metastasis (LNM), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and primary tumor size >= 6 cm were significant variables related to OS. CA19-9 >= 1,000 U/mL was statistically related to prognosis, as was CA19-9 >= 500 U/mL without obstructive jaundice. There was no significant relationship between abdominal and/or back pain and OS, but patients with moderate or severe pain accompanied by tumor size >= 4 cm or 10 times higher CA19-9 levels had worse prognosis. Conclusions: For clearly resectable pancreatic cancer with R0 resection, the high-risk features were clarified. Abdominal and/or back pain may not be used as a prognostic indicator alone, though combined with CA19-9 or tumor size it may be more valuable for predicting prognosis.
WOS关键词ADJUVANT CHEMOTHERAPY ; GEMCITABINE ; SURVIVAL
资助项目Guangdong Medical Science and Technology Research Fund[A2020240]
WOS研究方向Surgery
语种英语
WOS记录号WOS:000622479000026
出版者AME PUBL CO
资助机构Guangdong Medical Science and Technology Research Fund
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/120902]  
专题中国科学院合肥物质科学研究院
通讯作者Chen, Yuqing; Lu, Yanan
作者单位1.Sun Yat Sen Univ, Dept Anesthesiol, Sun Yat Sen Mem Hosp, Guangzhou, Peoples R China
2.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Stomatol, Guangzhou, Peoples R China
3.Chinese Acad Sci, Dept Anesthesiol, Canc Hosp, Hangzhou, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Dongni,Wang, Jiangling,Liu, Ting,et al. Quantitative definitions of pain, CA19-9, and tumor size as high-risk features of resectable pancreatic cancer: a single-center retrospective cohort study[J]. GLAND SURGERY,2021,10.
APA Xu, Dongni.,Wang, Jiangling.,Liu, Ting.,Huang, Zhuoshan.,Luo, Jianwei.,...&Lu, Yanan.(2021).Quantitative definitions of pain, CA19-9, and tumor size as high-risk features of resectable pancreatic cancer: a single-center retrospective cohort study.GLAND SURGERY,10.
MLA Xu, Dongni,et al."Quantitative definitions of pain, CA19-9, and tumor size as high-risk features of resectable pancreatic cancer: a single-center retrospective cohort study".GLAND SURGERY 10(2021).

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来源：合肥物质科学研究院

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