Prognostic and clinical significance of Solute Carrier Family 7 Member 1 in ovarian cancer
文献类型：期刊论文
| 作者 | Gong, Wangang1,2; Chen, Yongyi1,2; Zhang, Yingli1,2 |
| 刊名 | TRANSLATIONAL CANCER RESEARCH
 |
| 出版日期 | 2021-02-01 |
| 卷号 | 10 |
| 关键词 | Ovarian cancer (OC) SLC7A1 relapse-free survival |
| ISSN号 | 2218-676X |
| DOI | 10.21037/tcr-20-2744 |
| 通讯作者 | Zhang, Yingli(zhangyl@zjcc.org.cn) |
| 英文摘要 | Background: Members of the solute carrier (SLC)7 family are known to play important roles in tumorigenesis and development. However, the prognostic significance of the SLC7 family in ovarian cancer (OC) remains unknown. Methods: Expression patterns of SLC7 family members in OC were analyzed using gene expression profiling interactive analysis (GEPIA). The Kaplan-Meier plotter was applied to evaluate associations of the SLC7 gene family with prognosis of OC. SLC7A1 expression was additionally analyzed via immunohistochemical staining. chi(2), Kaplan-Meier and Cox regression analysis were used to evaluate the relationship between SLC7A1 expression and clinicopathological features, platinum resistance and prognosis in patients with high-grade serous ovarian cancer (HGSOC). Results: The GEPIA dataset revealed the abundant expression of SLC7A1, SLC7A4, and SLC7A7, and conversely, the low expression of SLC7A2 and SLC7A8 in OC relative to normal tissue samples. Kaplan-Meier survival analysis further indicated that high SLC7A1 and low SLC7A2 mRNA levels were significantly associated with overall survival (P<0.05). Positive SLC7A1 expression was detected in 65 (58.1%) HGSOC tissue samples, but not in all normal ovarian tissue samples (100%), indicating that the expression of SLC7A1 in HGSOC tissues was significantly higher than that in normal ovarian tissues (P<0.001). Additionally, expression of SLC7A1 was negatively associated with relapse-free survival (RFS; P<0.05). Conclusions: SLC7A1 is a potential prognostic biomarker of OC. |
| WOS关键词 | SLC TRANSPORTERS ; EXPRESSION ; RESISTANCE |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000624363300004 |
| 出版者 | AME PUBL CO |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/120909]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhang, Yingli |
| 作者单位 | 1.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gong, Wangang,Chen, Yongyi,Zhang, Yingli. Prognostic and clinical significance of Solute Carrier Family 7 Member 1 in ovarian cancer[J]. TRANSLATIONAL CANCER RESEARCH,2021,10. |
| APA | Gong, Wangang,Chen, Yongyi,&Zhang, Yingli.(2021).Prognostic and clinical significance of Solute Carrier Family 7 Member 1 in ovarian cancer.TRANSLATIONAL CANCER RESEARCH,10. |
| MLA | Gong, Wangang,et al."Prognostic and clinical significance of Solute Carrier Family 7 Member 1 in ovarian cancer".TRANSLATIONAL CANCER RESEARCH 10(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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