Effects of dibutyl phthalate on lipid metabolism in liver and hepatocytes based on PPAR alpha/SREBP-1c/FAS/GPAT/AMPK signal pathway
文献类型：期刊论文
| 作者 | Zhang, Wang2; Li, Jing-Ya1,3; Wei, Xiao-Chen2; Wang, Qian2; Yang, Ji-Yang2; Hou, Huan2; Du, Zi-Wei2; Wu, Xin-An2 |
| 刊名 | FOOD AND CHEMICAL TOXICOLOGY
 |
| 出版日期 | 2021-03-01 |
| 卷号 | 149 |
| 关键词 | DBP PPAR alpha AMPK Lipid metabolism Liver function |
| ISSN号 | 0278-6915 |
| DOI | 10.1016/j.fct.2021.112029 |
| 通讯作者 | Wu, Xin-An(wuxinan@boe.com.cn) |
| 英文摘要 | Phateacid esters (PAEs), such as dibutyl phthalate (DBP), have been widely used and human exposure results into serious toxic effects; such as the development of fatty liver disease. In the present study, SD rat models for in vivo study (normal and fatty liver model group) and hepatocytes for in vitro study (normal and abnormal lipid metabolism model group) were established to determine the effects of DBP on liver function and discover the possible mechanisms. Meanwhile, the peroxisome proliferator activated receptor (PPAR alpha) blocker, GW6471, with the Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) activator, AICAR, were applied in vitro study to clarify the role of PPAR alpha/SREBP-1c/FAS/GPAT/AMPK signal pathway in the process. Results suggested that DBP could activate PPAR alpha signaling pathway and affected the protein expression of SREBP, FAS and GPAT to cause hyperlipidemia and abnormal liver function. DBP also could inhibit the phosphorylation and activation of AMPK to inhibit the decomposition and metabolism of lipids. Interestingly, the effects of DBP could be alleviated by GW6471 and AICAR. Our experimental results provide reliable evidence that DBP exposure could further induce liver lipid metabolism disorder and other hepatic toxicity through PPAR alpha/SREBP-1c/FAS/ GPAT/AMPK signal pathway. |
| 资助项目 | Anhui Province Scientific and Technological Key Project (China)[1301042217] |
| WOS研究方向 | Food Science & Technology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000632256600032 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 资助机构 | Anhui Province Scientific and Technological Key Project (China) |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/121065]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wu, Xin-An |
| 作者单位 | 1.Univ Sci & Technol China, Dept Biol Phys, Hefei 230026, Peoples R China 2.Hefei BOE Hosp, Dept Pharm, Hefei, Peoples R China 3.Chinese Acad Sci, Inst Intelligent Machines, Hefei 230031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Wang,Li, Jing-Ya,Wei, Xiao-Chen,et al. Effects of dibutyl phthalate on lipid metabolism in liver and hepatocytes based on PPAR alpha/SREBP-1c/FAS/GPAT/AMPK signal pathway[J]. FOOD AND CHEMICAL TOXICOLOGY,2021,149. |
| APA | Zhang, Wang.,Li, Jing-Ya.,Wei, Xiao-Chen.,Wang, Qian.,Yang, Ji-Yang.,...&Wu, Xin-An.(2021).Effects of dibutyl phthalate on lipid metabolism in liver and hepatocytes based on PPAR alpha/SREBP-1c/FAS/GPAT/AMPK signal pathway.FOOD AND CHEMICAL TOXICOLOGY,149. |
| MLA | Zhang, Wang,et al."Effects of dibutyl phthalate on lipid metabolism in liver and hepatocytes based on PPAR alpha/SREBP-1c/FAS/GPAT/AMPK signal pathway".FOOD AND CHEMICAL TOXICOLOGY 149(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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