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Highly sensitive T-1-T-2 dual-mode MRI probe based on ultra-small gadolinium oxide-decorated iron oxide nanocrystals

文献类型：期刊论文

作者Miao, Yashuang2; Chen, Peirong2; Yan, Miao3,4; Xiao, Jianmin3,4; Hong, Biao3,4; Zhou, Ke1; Zhang, Guilong5; Qian, Junchao1; Wu, Zhengyan3,4
刊名BIOMEDICAL MATERIALS
出版日期2021-07-01
卷号16
ISSN号1748-6041
关键词iron oxide nanocrystals gadolinium oxide-decorated superparamagnetism dual-mode magnetic resonance imaging
DOI10.1088/1748-605X/abef54
通讯作者Chen, Peirong(chenpeirong@ahau.edu.cn) ; Qian, Junchao(qianjunchao@hmfl.ac.cn) ; Wu, Zhengyan(zywu@ipp.ac.cn)
英文摘要Single-mode magnetic resonance imaging (MRI) contrast agents (CAs) in clinical settings are easily disturbed by calcification, bleeding, and adipose signals, which result in inaccurate diagnoses. In this study, we developed a highly efficient T-1-T-2 dual-mode MRI CA using an ultra-small gadolinium oxide-decorated magnetic iron oxide nanocrystal (GMIO). The gadolinium element could effectively alter the magnetic properties of the GMIO from soft-ferromagnetism to superparamagnetism. In addition, when the Gd/Fe ratio was 15% (designated as GMIO-2), the GMIO-2 possessed the best superparamagnetism and highest magnetism. Subsequently, T-1 and T-2 values of GMIO-2 were measured through a series of turbo spin-echo images and then multi-spin echo sequence, respectively. Based on this, T-1 and T-2 relaxivities of GMIO-2 were calculated and were the highest (r(1): 1.306 m M-1 s(-1) and r(2): 234.5 m M-1 s(-1)) when compared to other groups. The cytotoxicity of GMIO-2 was negligible under a wide range of dosages, thus exhibiting excellent cell biocompatibility. Moreover, GMIO-2 could quickly diffuse into cells, leading to its effective accumulation. The systemic delivery of GMIO-2 resulted in an excellent T-1-T-2 dual-mode MRI contrast effect in kidneys, which is expected to improve the diagnosis of kidney lesions. Therefore, this work provides a promising candidate for the development of a T-1-T-2 dual-mode MRI CA.
资助项目National Key R&D Program of China[2018YFD0300903-4] ; Science and Technology Service Programs of Chinese Academy of Sciences[KFJ-STS-QYZD-115] ; Natural Science Foundation of Anhui Province[1808085MB38] ; Special Project of Central Government for Local Science and Technology Development of Shandong Province[YDZX20203700001291]
WOS研究方向Engineering ; Materials Science
语种英语
出版者IOP PUBLISHING LTD
WOS记录号WOS:000635908900001
资助机构National Key R&D Program of China ; Science and Technology Service Programs of Chinese Academy of Sciences ; Natural Science Foundation of Anhui Province ; Special Project of Central Government for Local Science and Technology Development of Shandong Province
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/121119]  
专题中国科学院合肥物质科学研究院
通讯作者Chen, Peirong; Qian, Junchao; Wu, Zhengyan
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei Canc Hosp,Inst Hlth & Med Technol, Hefei 230031, Peoples R China
2.Anhui Agr Univ, Sch Sci, Dept Appl Chem, Hefei 230036, Peoples R China
3.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China
4.Univ Sci & Technol China, Hefei 230026, Peoples R China
5.Binzhou Med Univ, Sch Pharm, Key Lab Prescript Effect & Clin Evaluat, State Adm Tradit Chinese Med China, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 Miao, Yashuang,Chen, Peirong,Yan, Miao,et al. Highly sensitive T-1-T-2 dual-mode MRI probe based on ultra-small gadolinium oxide-decorated iron oxide nanocrystals[J]. BIOMEDICAL MATERIALS,2021,16.
APA Miao, Yashuang.,Chen, Peirong.,Yan, Miao.,Xiao, Jianmin.,Hong, Biao.,...&Wu, Zhengyan.(2021).Highly sensitive T-1-T-2 dual-mode MRI probe based on ultra-small gadolinium oxide-decorated iron oxide nanocrystals.BIOMEDICAL MATERIALS,16.
MLA Miao, Yashuang,et al."Highly sensitive T-1-T-2 dual-mode MRI probe based on ultra-small gadolinium oxide-decorated iron oxide nanocrystals".BIOMEDICAL MATERIALS 16(2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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