A DNA Damage-Repair Dynamic Model for HRS/IRR Effects of C.elegans Induced by Neutron Irradiation
文献类型：期刊论文
| 作者 | Feng, Guangyan2,3; Zhang, Lianxin1,2; Yang, Zhanguo1,2; Zhang, Yong2 ; Zhang, Siwei1,2; Li, Taosheng2; Xu, Zhao2
|
| 刊名 | DOSE-RESPONSE
 |
| 出版日期 | 2021 |
| 卷号 | 19 |
| ISSN号 | 1559-3258 |
| 关键词 | hyper-radiosensitivity neutron C elegans surviving-fraction damage-repair model |
| DOI | 10.1177/15593258211001254 |
| 通讯作者 | Xu, Zhao(zhao.xu@inest.cas.cn) |
| 英文摘要 | Neutron irradiation which could trigger severe biological effects, is being applied in nuclear plants, radiotherapy, and aerospace gradually. Low dose hyper-radiosensitivity response of low Linear Energy Transfer (LET) irradiation on the cell survival has become a matter of great interest since its discovery, but a few research have been done on this response induced by neutron irradiation. To investigate this response induced by neutron irradiation, Caenorhabditis elegans (C. elegans) was irradiated by neutron irradiation. The surviving fraction of C. elegans on the 12th day after irradiation was analyzed, which showed a hyper-radiosensitive response at low doses and followed by an increase in survival fraction at slightly higher doses. The finding of this work that neutron irradiation decreased the surviving fraction in a non-dose-dependent manner was different from previous low-LET irradiation studies. To understand the experimental results, a DNA damage-repair model was introduced. By comparing experimental results with theoretical analyses, we suggest that the low dose hyper-radiosensitivity response of neutron irradiation may possible related to different radiation types and DNA damage recognition proteins and immune system of C. elegans. |
| 资助项目 | National Magnetic Confinement Fusion Science Program of China[2014GB112006] ; Chinese Academy of Science[YZJJ2020QN31] |
| WOS研究方向 | Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging ; Toxicology |
| 语种 | 英语 |
| 出版者 | SAGE PUBLICATIONS INC |
| WOS记录号 | WOS:000629356200001 |
| 资助机构 | National Magnetic Confinement Fusion Science Program of China ; Chinese Academy of Science |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/121141]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Xu, Zhao |
| 作者单位 | 1.Univ Sci & Technol China, Hefei, Anhui, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, Hefei, Anhui, Peoples R China 3.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Guangyan,Zhang, Lianxin,Yang, Zhanguo,et al. A DNA Damage-Repair Dynamic Model for HRS/IRR Effects of C.elegans Induced by Neutron Irradiation[J]. DOSE-RESPONSE,2021,19. |
| APA | Feng, Guangyan.,Zhang, Lianxin.,Yang, Zhanguo.,Zhang, Yong.,Zhang, Siwei.,...&Xu, Zhao.(2021).A DNA Damage-Repair Dynamic Model for HRS/IRR Effects of C.elegans Induced by Neutron Irradiation.DOSE-RESPONSE,19. |
| MLA | Feng, Guangyan,et al."A DNA Damage-Repair Dynamic Model for HRS/IRR Effects of C.elegans Induced by Neutron Irradiation".DOSE-RESPONSE 19(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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