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Molecular Characteristics of Genes and the Immune Microenvironment of a Rare Chest Malignant Tumor (Pulmonary Clear Cell Sarcoma): A Case Report

文献类型：期刊论文

作者Xu, Xiaoling2,3; Wang, Ding1; Wu, Wei4; Lu, Hongyang2,3,5
刊名FRONTIERS IN ONCOLOGY
出版日期2021-03-22
卷号11
关键词clear cell sarcoma next-generation sequencing lung EWS-ATF1 PD-L1 TIGIT
ISSN号2234-943X
DOI10.3389/fonc.2021.664883
通讯作者Lu, Hongyang(luhy@zjcc.org.cn)
英文摘要Pulmonary clear cell sarcoma is a rare malignant tumor that has rarely been reported and is challenging to diagnose, especially when differentiating from malignant melanoma. Currently, EWSR1-ATF1 is the key marker for distinguishing clear cell sarcoma from melanoma, but IHC has diagnostic limitations. We report a patient diagnosed with pulmonary clear cell sarcoma, in which an NGS was used to help with the pathological diagnosis. The exposure to the immune microenvironment in pulmonary clear cell sarcoma suggests that TIGIT-related drugs may be a new and effective treatment for this rare disease. Immune microenvironment-related markers, including PD-L1, CD8, TIM3, LAG3, and CD163, were negatively expressed in pulmonary clear cell sarcoma.
资助项目Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)
WOS研究方向Oncology
语种英语
WOS记录号WOS:000636668900001
出版者FRONTIERS MEDIA SA
资助机构Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/121295]  
专题中国科学院合肥物质科学研究院
通讯作者Lu, Hongyang
作者单位1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Thorac Surg, Hangzhou, Peoples R China
2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Thorac Oncol, Hangzhou, Peoples R China
3.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China
4.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Pathol, Hangzhou, Peoples R China
5.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Zhejiang Key Lab Diag & Treatment Technol Thorac, Hangzhou, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Xiaoling,Wang, Ding,Wu, Wei,et al. Molecular Characteristics of Genes and the Immune Microenvironment of a Rare Chest Malignant Tumor (Pulmonary Clear Cell Sarcoma): A Case Report[J]. FRONTIERS IN ONCOLOGY,2021,11.
APA Xu, Xiaoling,Wang, Ding,Wu, Wei,&Lu, Hongyang.(2021).Molecular Characteristics of Genes and the Immune Microenvironment of a Rare Chest Malignant Tumor (Pulmonary Clear Cell Sarcoma): A Case Report.FRONTIERS IN ONCOLOGY,11.
MLA Xu, Xiaoling,et al."Molecular Characteristics of Genes and the Immune Microenvironment of a Rare Chest Malignant Tumor (Pulmonary Clear Cell Sarcoma): A Case Report".FRONTIERS IN ONCOLOGY 11(2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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