Molecular Characteristics of Genes and the Immune Microenvironment of a Rare Chest Malignant Tumor (Pulmonary Clear Cell Sarcoma): A Case Report
文献类型:期刊论文
作者 | Xu, Xiaoling2,3; Wang, Ding1; Wu, Wei4; Lu, Hongyang2,3,5 |
刊名 | FRONTIERS IN ONCOLOGY
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出版日期 | 2021-03-22 |
卷号 | 11 |
关键词 | clear cell sarcoma next-generation sequencing lung EWS-ATF1 PD-L1 TIGIT |
ISSN号 | 2234-943X |
DOI | 10.3389/fonc.2021.664883 |
通讯作者 | Lu, Hongyang(luhy@zjcc.org.cn) |
英文摘要 | Pulmonary clear cell sarcoma is a rare malignant tumor that has rarely been reported and is challenging to diagnose, especially when differentiating from malignant melanoma. Currently, EWSR1-ATF1 is the key marker for distinguishing clear cell sarcoma from melanoma, but IHC has diagnostic limitations. We report a patient diagnosed with pulmonary clear cell sarcoma, in which an NGS was used to help with the pathological diagnosis. The exposure to the immune microenvironment in pulmonary clear cell sarcoma suggests that TIGIT-related drugs may be a new and effective treatment for this rare disease. Immune microenvironment-related markers, including PD-L1, CD8, TIM3, LAG3, and CD163, were negatively expressed in pulmonary clear cell sarcoma. |
资助项目 | Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) |
WOS研究方向 | Oncology |
语种 | 英语 |
WOS记录号 | WOS:000636668900001 |
出版者 | FRONTIERS MEDIA SA |
资助机构 | Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/121295] ![]() |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Lu, Hongyang |
作者单位 | 1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Thorac Surg, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Thorac Oncol, Hangzhou, Peoples R China 3.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China 4.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Pathol, Hangzhou, Peoples R China 5.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Zhejiang Key Lab Diag & Treatment Technol Thorac, Hangzhou, Peoples R China |
推荐引用方式 GB/T 7714 | Xu, Xiaoling,Wang, Ding,Wu, Wei,et al. Molecular Characteristics of Genes and the Immune Microenvironment of a Rare Chest Malignant Tumor (Pulmonary Clear Cell Sarcoma): A Case Report[J]. FRONTIERS IN ONCOLOGY,2021,11. |
APA | Xu, Xiaoling,Wang, Ding,Wu, Wei,&Lu, Hongyang.(2021).Molecular Characteristics of Genes and the Immune Microenvironment of a Rare Chest Malignant Tumor (Pulmonary Clear Cell Sarcoma): A Case Report.FRONTIERS IN ONCOLOGY,11. |
MLA | Xu, Xiaoling,et al."Molecular Characteristics of Genes and the Immune Microenvironment of a Rare Chest Malignant Tumor (Pulmonary Clear Cell Sarcoma): A Case Report".FRONTIERS IN ONCOLOGY 11(2021). |
入库方式: OAI收割
来源:合肥物质科学研究院
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