Different characteristics of infants diagnosed with congenital choledochal malformation prenatally or postnatally
文献类型：期刊论文
| 作者 | Chen, Wei2; Geng, Jia1; Tan, Ya-lan3; Zhao, Lian2; Jia, Hui-hui2; Guo, Wan-liang2 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2021-01-08 |
| 卷号 | 11 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-020-79569-4 |
| 通讯作者 | Guo, Wan-liang(gwlsuzhou@163.com) |
| 英文摘要 | The general condition, clinical and pathological characteristics, and treatment regimens of patients prenatally and postnatally diagnosed with congenital choledochal malformation (CM) were analyzed in order to investigate the clinical significance of early diagnosis, treatment, and intervention in CM. We retrospectively analyzed 33 children who were admitted to the Children's Hospital of Soochow University between 1 March 2010 and 31 May 2019, and their diagnosis of CM was confirmed by radiological, surgical and pathological findings. All the patients were under 36 months of age. The patients were divided into prenatally diagnosed and postnatally diagnosed groups. There were 16 and 17 CM patients in the prenatally and postnatally diagnosed groups, respectively, with a preponderance of females in both groups. Compared with the prenatally diagnosed group, the postnatally diagnosed group had a higher incidence of abdominal pain and vomiting (p<0.05) and higher AST, GGT, and TB levels (p<0.05). Although postoperative histopathological examination showed inflammation in both groups, congestion in the cyst walls and fibrous tissue hyperplasia were more significant in the postnatally diagnosed group (p<0.05). In addition, operation time, length of time required to resume a normal diet after surgery, and total length of hospitalization differed between the 2 groups (p<0.05), with the prenatally diagnosed group having a relatively longer operation time and taking longer to resume a normal diet after surgery. However, the total length of hospitalization in the prenatally diagnosed group was shorter than that in the postnatally diagnosed group. Compared with prenatally diagnosed CM patients, more symptoms, greater severity of symptoms, and more time to recovery after surgery were observed in postnatally diagnosed CM patients. |
| 资助项目 | National Natural Science Foundation[81971685] ; Science and Technology Project of Suzhou[SS201868] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000634374700012 |
| 出版者 | NATURE RESEARCH |
| 资助机构 | National Natural Science Foundation ; Science and Technology Project of Suzhou |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/121337]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Guo, Wan-liang |
| 作者单位 | 1.3rd Hosp Yulin City, Clin Lab, Yulin 719000, Peoples R China 2.Soochow Univ, Dept Radiol, Childrens Hosp, Suzhou 215025, Peoples R China 3.Univ Chinese Acad Sci, Dept Radiol, Canc Hosp, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Wei,Geng, Jia,Tan, Ya-lan,et al. Different characteristics of infants diagnosed with congenital choledochal malformation prenatally or postnatally[J]. SCIENTIFIC REPORTS,2021,11. |
| APA | Chen, Wei,Geng, Jia,Tan, Ya-lan,Zhao, Lian,Jia, Hui-hui,&Guo, Wan-liang.(2021).Different characteristics of infants diagnosed with congenital choledochal malformation prenatally or postnatally.SCIENTIFIC REPORTS,11. |
| MLA | Chen, Wei,et al."Different characteristics of infants diagnosed with congenital choledochal malformation prenatally or postnatally".SCIENTIFIC REPORTS 11(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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