Correlation between preoperative ultrasonic features of medullary thyroid carcinoma and postoperative recurrence
文献类型：期刊论文
| 作者 | Zhu, Qiaodan2; Xu, Dong1,3,4,5,6 |
| 刊名 | BMC CANCER
 |
| 出版日期 | 2021-04-01 |
| 卷号 | 21 |
| 关键词 | Medullary thyroid carcinoma Ultrasound Recurrence Calcitonin |
| DOI | 10.1186/s12885-021-07953-y |
| 通讯作者 | Xu, Dong(xudong@zjcc.org.cn) |
| 英文摘要 | BackgroundTo investigate the factors that affect postoperative recurrence in medullary thyroid carcinoma (MTC) patients, including preoperative ultrasonic characteristics and other factors.MethodA retrospective analysis of 7 MTC patients who underwent the first thyroid surgery from 2009 to 2018 and who had complete follow-up data was conducted. According to the follow-up results, these patients were divided into the recurrence group (17 cases) and non-recurrence group (57 cases). The preoperative ultrasound characteristics, preoperative and postoperative calcitonin levels, and general informations of the two groups were recorded, respectively. Univariate and multivariate analyses were performed.ResultsSingle factor Kaplan-Meier (K-M) analysis showed that: ? Preoperative ultrasonic characteristics including tumor size >40.0mm, capsular invasion, and metastatic cervical lymph nodes, as well as preoperative calcitonin level>565.8pg/ml, and postoperative calcitonin (within one week) level>45.0pg/ml were positively correlated with the risk of postoperative recurrence of MTC (P<0.05); ? There was no evidence to show that sex and age had a statistically significant effect on postoperative recurrence of MTC (P>0.05). Multivariate Cox regression analysis showed that metastatic lymph nodes shown by ultrasound (HR=5.368, 95%CI 1.063-27.104, P=0.042) was an independent risk factor for postoperative recurrence of MTC.ConclusionsMTC patients with metastatic lymph nodes shown by ultrasound are prone to postoperative recurrence of MTC. In addition, MTC patients with a tumor >40.0mm, capsular invasion, preoperative calcitonin level>565.8pg/ml, and postoperative calcitonin level>45.0pg/ml are more likely to have postoperative recurrence. |
| 资助项目 | National Natural Science Foundation of China[81871370] ; National Natural Science Foundation of China[82071946] ; Natural Science Foundation of Zhejiang Province (CN)[LSD19H180001] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000636446600001 |
| 出版者 | BMC |
| 资助机构 | National Natural Science Foundation of China ; Natural Science Foundation of Zhejiang Province (CN) |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/121491]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Xu, Dong |
| 作者单位 | 1.Key Lab Head & Neck Canc Translat Res Zhejiang Pr, Hangzhou 310022, Zhejiang, Peoples R China 2.Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Zhejiang, Peoples R China 3.Wenzhou Med Univ, Wenzhou 325600, Zhejiang, Peoples R China 4.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, 1 East Banshan Rd, Hangzhou 310022, Zhejiang, Peoples R China 5.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou 310022, Zhejiang, Peoples R China 6.Zhejiang Prov Res Ctr Canc Intelligent Diag & Mol, Hangzhou 310022, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Qiaodan,Xu, Dong. Correlation between preoperative ultrasonic features of medullary thyroid carcinoma and postoperative recurrence[J]. BMC CANCER,2021,21. |
| APA | Zhu, Qiaodan,&Xu, Dong.(2021).Correlation between preoperative ultrasonic features of medullary thyroid carcinoma and postoperative recurrence.BMC CANCER,21. |
| MLA | Zhu, Qiaodan,et al."Correlation between preoperative ultrasonic features of medullary thyroid carcinoma and postoperative recurrence".BMC CANCER 21(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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