The association of CMTM6 expression with prognosis and PD-L1 expression in triple-negative breast cancer
文献类型：期刊论文
| 作者 | Tian, Yiping2,3; Sun, Xiaohui1; Cheng, Guoping2,3; Ji, Enming2,3; Yang, Shifeng2,3; Feng, Jianguo3,4; Zheng, Linfeng2,3 |
| 刊名 | ANNALS OF TRANSLATIONAL MEDICINE
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| 出版日期 | 2021 |
| 卷号 | 9 |
| 关键词 | CMTM6 PD-L1 triple-negative breast cancer (TNBC) immunohistochemistry (IHC) polymerase chain reaction (PCR) prognosis |
| ISSN号 | 2305-5839 |
| DOI | 10.21037/atm-20-7616 |
| 通讯作者 | Zheng, Linfeng(zhenglf@zjcc.org.cn) |
| 英文摘要 | Background: Immune checkpoint inhibitors play a vital role in triple-negative breast cancer (TNBC) immunotherapy. A recent study showed that chemokine-like factor (CKLF)-like MARVEL transmembrane domain containing 6 (CMTM6) has a crucial role in programmed death-ligand 1 (PD-L1) stability. The aim of this study was to investigate the relationship between CMTM6 and PD-L1 in TNBC and the association with clinical characteristics. Methods: A total of 143 patients, including 75 with human epidermal growth factor receptor 2 (HER2)-driven breast cancer and 68 with TNBC, were included in this study. In 83 paired primary breast cancers (PBCs) and metastatic breast cancers (MBC) comprising 45 HER2-driven breast cancers and 38 TNBC, CMTM6 and PD-L1 were detected based on immunohistochemistry (IHC) with FFPE tissues. Another 60 PBCs comprising 30 HER2-driven breast cancers and 30 TNBC in order to detect CMTM6 and PD-L1 mRNA expressions based on real-time polymerase chain reaction (RT-PCR) using frozen tissues. Furthermore, 153 patients comprising 30 TNBC and 123 HER2-driven breast cancer based on The Cancer Genome Atlas (TCGA) database were used to confirm the difference mRNA expression. Results: The expression of CMTM6 in patients with TNBC was significantly higher than in those with HER2-driven PBC (IHC, P=0.036, mRNA, P=0.036, TCGA dataset, P=0.039). CMTM6 was correlated with PD-L1 based on IHC in triple-negative MBC (P=0.004); the same result was found based on mRNA data in triple-negative PBC (P=0.021). Moreover, a high expression of CMTM6 in TNBC was associated with poor progression-free survival (PFS) (P=0.030, 95% CI: 1.08-4.57, HR=2.22). After multiple Cox regression analysis, CMTM6 in TNBC emerged as an independent risk factor for PFS (P=0.027, 95% CI: 1.11-5.20, HR=2.40). The expression of PD-L1 was negatively correlated with lymph node metastasis (P=0.026) and was not associated with PFS. Conclusions: The expression of CMTM6 was higher in TNBC than in HER2-driven breast cancer. In TNBC, CMTM6 was correlated with PD-L1 expression, and potentially could be used as an independent risk factor for predicting PFS. |
| 资助项目 | Medical Health Science and Technology Project of Zhejiang Provincial Health Commission[2018KY030] ; Natural Science Foundation of Zhejiang Province[LQ21H260001] |
| WOS研究方向 | Oncology ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000636046800009 |
| 出版者 | AME PUBL CO |
| 资助机构 | Medical Health Science and Technology Project of Zhejiang Provincial Health Commission ; Natural Science Foundation of Zhejiang Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/121578]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zheng, Linfeng |
| 作者单位 | 1.Zhejiang Chinese Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Dept Pathol, Canc Hosp, Zhejiang Canc Hosp, Hangzhou, Peoples R China 3.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou, Peoples R China 4.Univ Chinese Acad Sci, Dept Expt Res Ctr, Canc Hosp, Zhejiang Canc Hosp, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Yiping,Sun, Xiaohui,Cheng, Guoping,et al. The association of CMTM6 expression with prognosis and PD-L1 expression in triple-negative breast cancer[J]. ANNALS OF TRANSLATIONAL MEDICINE,2021,9. |
| APA | Tian, Yiping.,Sun, Xiaohui.,Cheng, Guoping.,Ji, Enming.,Yang, Shifeng.,...&Zheng, Linfeng.(2021).The association of CMTM6 expression with prognosis and PD-L1 expression in triple-negative breast cancer.ANNALS OF TRANSLATIONAL MEDICINE,9. |
| MLA | Tian, Yiping,et al."The association of CMTM6 expression with prognosis and PD-L1 expression in triple-negative breast cancer".ANNALS OF TRANSLATIONAL MEDICINE 9(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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