Towards customized cancer vaccines: a promising filed in personalized cancer medicine
文献类型：期刊论文
| 作者 | Xu, Xiaoling1,2; Zhou, Zichao1,3; Li, Hui1,2; Fan, Yun1,2 |
| 刊名 | EXPERT REVIEW OF VACCINES
 |
| 出版日期 | 2021-04-04 |
| 关键词 | Cancer vaccines tumor neoantigens personalized treatment mutations |
| ISSN号 | 1476-0584 |
| DOI | 10.1080/14760584.2021.1909479 |
| 通讯作者 | Fan, Yun(fanyun@zjcc.org.cn) |
| 英文摘要 | Introduction Cancer remains a major source of disease burden worldwide. Although cancer vaccines have been developed, most currently available cancer vaccines have limited therapeutic efficacy. Recent research using novel sequencing and bioinformatic tools has led scientists to realize that each tumor harbors a unique set of genetic mutations that can manifest as tumor-specific neoantigens. Therefore, it would be useful to develop personalized cancer vaccines that target neoantigens, which might improve the efficacy of these cancer treatments. Areas covered This review covers cancer vaccine development and the emerging field of personalized cancer vaccines, with a discussion of future clinical trials for this promising treatment strategy. Expert opinion Developing vaccines to treat tumors is one of the most promising and exciting fields in cancer research. However, cancer vaccines have shown limited efficacy in clinical trials for several decades, which may be related to the unique and complex processes underlying tumor development and progression. Recent studies have indicated that tumors express highly specific neoantigens, which are distinct from self-antigens. Thus, developing cancer vaccines that target these tumor-specific neoantigens is a promising strategy for developing personalized cancer vaccines. |
| 资助项目 | National Natural Science Foundation of China[81802995] ; Zhejiang Natural Science Foundation[LY16H160039] ; Zhejiang Province Public Welfare Funds[LGF19H280004] ; Medical Science and Technology Project of Zhejiang Province[2018RC020] ; Medical Science and Technology Project of Zhejiang Province[2018KY024] |
| WOS研究方向 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000636880500001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 资助机构 | National Natural Science Foundation of China ; Zhejiang Natural Science Foundation ; Zhejiang Province Public Welfare Funds ; Medical Science and Technology Project of Zhejiang Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/121600]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Fan, Yun |
| 作者单位 | 1.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Med Oncol, Hangzhou, Peoples R China 3.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Thorac Surg, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Xiaoling,Zhou, Zichao,Li, Hui,et al. Towards customized cancer vaccines: a promising filed in personalized cancer medicine[J]. EXPERT REVIEW OF VACCINES,2021. |
| APA | Xu, Xiaoling,Zhou, Zichao,Li, Hui,&Fan, Yun.(2021).Towards customized cancer vaccines: a promising filed in personalized cancer medicine.EXPERT REVIEW OF VACCINES. |
| MLA | Xu, Xiaoling,et al."Towards customized cancer vaccines: a promising filed in personalized cancer medicine".EXPERT REVIEW OF VACCINES (2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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