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miRSM: an R package to infer and analyse miRNA sponge modules in heterogeneous data

文献类型：期刊论文

作者Zhang, Junpeng2,3; Liu, Lin4; Xu, Taosheng1; Zhang, Wu5; Zhao, Chunwen3; Li, Sijing3; Li, Jiuyong4; Rao, Nini2,3; Le, Thuc Duy4
刊名RNA BIOLOGY
出版日期2021-04-08
ISSN号1547-6286
关键词miRNA lncRNA ceRNA miRNA sponge modules modular analysis
DOI10.1080/15476286.2021.1905341
通讯作者Zhang, Junpeng(zhangjunpeng_411@yahoo.com) ; Rao, Nini(raonn@uestc.edu.cn) ; Le, Thuc Duy(thuc.le@unisa.edu.au)
英文摘要In molecular biology, microRNA (miRNA) sponges are RNA transcripts which compete with other RNA transcripts for binding with miRNAs. Research has shown that miRNA sponges have a fundamental impact on tissue development and disease progression. Generally, to achieve a specific biological function, miRNA sponges tend to form modules or communities in a biological system. Until now, however, there is still a lack of tools to aid researchers to infer and analyse miRNA sponge modules from heterogeneous data. To fill this gap, we develop an R/Bioconductor package, miRSM, for facilitating the procedure of inferring and analysing miRNA sponge modules. miRSM provides a collection of 50 co-expression analysis methods to identify gene co-expression modules (which are candidate miRNA sponge modules), four module discovery methods to infer miRNA sponge modules and seven modular analysis methods for investigating miRNA sponge modules. miRSM will enable researchers to quickly apply new datasets to infer and analyse miRNA sponge modules, and will consequently accelerate the research on miRNA sponges.
资助项目National Natural Science Foundation of China[61720106004] ; National Natural Science Foundation of China[61902372] ; National Natural Science Foundation of China[61963001] ; National Natural Science Foundation of China[61702069] ; National Natural Science Foundation of China[61872405] ; Yunnan Fundamental Research Projects[202001AT070024] ; National Health & Medical Research Council (NHMRC)[1123042] ; Australian Research Council[DP170101306]
WOS研究方向Biochemistry & Molecular Biology
语种英语
出版者TAYLOR & FRANCIS INC
WOS记录号WOS:000637240500001
资助机构National Natural Science Foundation of China ; Yunnan Fundamental Research Projects ; National Health & Medical Research Council (NHMRC) ; Australian Research Council
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/121621]  
专题中国科学院合肥物质科学研究院
通讯作者Zhang, Junpeng; Rao, Nini; Le, Thuc Duy
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Intelligent Machines, Hefei, Anhui, Peoples R China
2.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Ctr Informat Biol, Chengdu, Sichuan, Peoples R China
3.Dali Univ, Sch Engn, Dali 671003, Yunnan, Peoples R China
4.Univ South Australia, UniSA STEM, Mawson Lakes, SA, Australia
5.Dali Univ, Sch Agr & Biol Sci, Dali, Yunnan, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Junpeng,Liu, Lin,Xu, Taosheng,et al. miRSM: an R package to infer and analyse miRNA sponge modules in heterogeneous data[J]. RNA BIOLOGY,2021.
APA Zhang, Junpeng.,Liu, Lin.,Xu, Taosheng.,Zhang, Wu.,Zhao, Chunwen.,...&Le, Thuc Duy.(2021).miRSM: an R package to infer and analyse miRNA sponge modules in heterogeneous data.RNA BIOLOGY.
MLA Zhang, Junpeng,et al."miRSM: an R package to infer and analyse miRNA sponge modules in heterogeneous data".RNA BIOLOGY (2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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