BCL2L13: physiological and pathological meanings
文献类型：期刊论文
| 作者 | Meng, Fei1,2,3; Sun, Naitong4; Liu, Dongyan1,2,3; Jia, Jia1,2,3; Xiao, Jun5; Dai, Haiming1,2 |
| 刊名 | CELLULAR AND MOLECULAR LIFE SCIENCES
 |
| 出版日期 | 2021-03-01 |
| 卷号 | 78 |
| 关键词 | BCL-rambo Autophagy Apoptosis Tumor Cerebrovascular accident Neurodegenerative disorders |
| ISSN号 | 1420-682X |
| DOI | 10.1007/s00018-020-03702-9 |
| 通讯作者 | Xiao, Jun(xiaojunpp@126.com) ; Dai, Haiming(daih@cmpt.ac.cn) |
| 英文摘要 | BCL2L13 is a BCL2-like protein. It has been discovered for two decades, now on the way to be a hotspot of research with its physiological and pathological meanings found in recent years. Start with the pro-apoptotic activity, there have been reported consecutively that BCL2L13 could also induce mitochondrial fragmentation, inhibit cell death and promote mitophagy. Similar to BNIP3, BCL2L13 cannot be indiscriminately categorized into pro- or anti-apoptotic proteins. It anchors in the mitochondrial outer membrane, and expresses in various cells and tissues. This article reviews for the first time that BCL2L13 functions in physiological processes, such as growth and development and energy metabolism, and its dysregulation participating in pathological processes, including cancer, bacterial infection, cardiovascular diseases and degenerative diseases, suggesting its important roles in these events. |
| 资助项目 | National Natural Science Foundation of China[31970701] ; National Natural Science Foundation of China[21772201] ; National Natural Science Foundation of China[82072807] ; Anhui Medical University ; Center of Medical Physics and Technology[LHJJ202006] ; Center of Medical Physics and Technology[LHJJ202007] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000642124100001 |
| 出版者 | SPRINGER BASEL AG |
| 资助机构 | National Natural Science Foundation of China ; Anhui Medical University ; Center of Medical Physics and Technology |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/121717]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Xiao, Jun; Dai, Haiming |
| 作者单位 | 1.Chinese Acad Sci, Hefei Canc Hosp, 350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Hlth & Med Technol, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China 3.Univ Sci & Technol China, Hefei 230026, Peoples R China 4.Third Peoples Hosp Yancheng, Dept Hematol, Yancheng 224001, Peoples R China 5.Univ Sci & Technol China, Div Life Sci & Med, Affiliated Hosp USTC 1, Dept Urol, Hefei 230001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Meng, Fei,Sun, Naitong,Liu, Dongyan,et al. BCL2L13: physiological and pathological meanings[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2021,78. |
| APA | Meng, Fei,Sun, Naitong,Liu, Dongyan,Jia, Jia,Xiao, Jun,&Dai, Haiming.(2021).BCL2L13: physiological and pathological meanings.CELLULAR AND MOLECULAR LIFE SCIENCES,78. |
| MLA | Meng, Fei,et al."BCL2L13: physiological and pathological meanings".CELLULAR AND MOLECULAR LIFE SCIENCES 78(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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