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Integrating DNA Nanotechnology with Aptamers for Biological and Biomedical Applications

文献类型：期刊论文

作者Huang, Zike2,3; Qiu, Liping3; Zhang, Tao1,2; Tan, Weihong2,3
刊名MATTER
出版日期2021-02-03
卷号4
ISSN号2590-2393
DOI10.1016/j.matt.2020.11.002
通讯作者Zhang, Tao(zhtao@zju.edu.cn) ; Tan, Weihong(tan@hnu.edu.cn)
英文摘要In addition to critical biological roles, DNA is also considered an excellent engineering material with unique characteristics of high programmability and addressability. Recent advances in DNA nano technology enable the rational design and precise fabrication of various exquisite DNA nanostructures, providing many new opportunities for technological uses. Meanwhile, the integration of DNA nanostructures with molecular recognition capacity can further expand the scope of their application. Particularly suited to this goal, aptamers are short single-stranded nucleic acids selected via an in vitro strategy called systematic evolution of ligands by exponential enrichment. As analogs to antibodies, aptamers can bind to various targets, such as small molecules, proteins, viruses, bacteria, and even whole cells. Apart from comparable specificity and affinity as antibodies, aptamers have several advantages, including small molecular weight, high designability, easy synthesis, and convenient modification. Indeed, the marriage of aptamers with DNA nanostructures has generated many powerful tools for advanced biological and biomedical applications. In this review, we summarize the recent progress, application, and prospect of aptamer-integrated DNA nanotechnology in the fields of biosensing, bioimaging, targeted drug delivery, bioregulation, and biomimicry.
资助项目National Natural Science Foundation of China[21827811] ; National Natural Science Foundation of China[91753109] ; National Natural Science Foundation of China[21922404] ; National Natural Science Foundation of China[21904118] ; National Natural Science Foundation of China[21275129] ; National Natural Science Foundation of China[61527806] ; National Key Research Program[2019YFA0905800] ; National Key Research Program[2018YFC1602900] ; Natural Science Foundation of Zhejiang Province[LY19B050006] ; Natural Science Foundation of Zhejiang Province[LY17B050008] ; State Key Laboratory of Industrial Control Technology[ICT1914]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:000632645300008
出版者ELSEVIER
资助机构National Natural Science Foundation of China ; National Key Research Program ; Natural Science Foundation of Zhejiang Province ; State Key Laboratory of Industrial Control Technology
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/121780]  
专题中国科学院合肥物质科学研究院
通讯作者Zhang, Tao; Tan, Weihong
作者单位1.Zhejiang Univ, Coll Control Sci & Engn, Res Ctr Analyt Instrumentat, Inst Intelligent Control & Syst,State Key Lab Ind, Hangzhou 310027, Peoples R China
2.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Basic Med & Canc IBMC, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
3.Hunan Univ, Coll Chem & Chem Engn, Coll Biol, Mol Sci & Biomed Lab MBL,State Key Lab Chemo Bios, Changsha 410082, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Zike,Qiu, Liping,Zhang, Tao,et al. Integrating DNA Nanotechnology with Aptamers for Biological and Biomedical Applications[J]. MATTER,2021,4.
APA Huang, Zike,Qiu, Liping,Zhang, Tao,&Tan, Weihong.(2021).Integrating DNA Nanotechnology with Aptamers for Biological and Biomedical Applications.MATTER,4.
MLA Huang, Zike,et al."Integrating DNA Nanotechnology with Aptamers for Biological and Biomedical Applications".MATTER 4(2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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