Surface morphology and payload synergistically caused an enhancement of the longitudinal relaxivity of a Mn3O4/PtOx nanocomposite for magnetic resonance tumor imaging
文献类型：期刊论文
| 作者 | Ji, Sihan1,2,7; Chen, Yaodong3; Zhao, Xianglong2,5; Cai, Yunyu1,7 ; Zhang, Xiaopeng2,4; Sun, Feilong2,4; Chen, Qi6; Deng, Qingmei6; Wang, Changhao2,5; Ma, Kun5
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| 刊名 | BIOMATERIALS SCIENCE
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| 出版日期 | 2021-04-07 |
| 卷号 | 9 |
| ISSN号 | 2047-4830 |
| DOI | 10.1039/d0bm01993c |
| 通讯作者 | Cai, Yunyu(yycai@issp.ac.cn) ; Hong, Bo(bhong@hmfl.ac.cn) ; Liang, Changhao(chliang@issp.ac.cn) |
| 英文摘要 | The construction of surface structures of manganese oxide nanoparticles (MONs) in order to promote their longitudinal relaxivity r(1) to surpass those of commercially available Gd(iii) complexes is still a significant challenge. Herein, we successfully obtained Mn3O4/PtOx nanocomposites (NCs) with an r(1) of 20.48 mM(-1) s(-1), four times higher than that of commercially available Gd-DTPA (5.11 mM(-1) s(-1)). The r(2)/r(1) ratio of these NCs is 1.46 lower than that of Gd-DTPA (2.38). This is the first time that such excellent T-1 contrast performance has been achieved using MONs via synergistically utilizing the surface morphology and surface payload. These NCs are composed of porous Mn3O4 "skeleton" nanostructures decorated with tiny PtOx nanoparticles (NPs) that are realized using laser ablation and irradiation in liquid and ion etching steps. Experimental results showed that the enlarged specific area of the porous Mn3O4/PtOx NCs and the payload of ultrafine PtOx NPs synergistically facilitated the T-1 contrast capabilities. The former favors sufficient proton-electron interactions and the latter reduces the global molecular tumbling motion. These NCs also exhibit an evident computed tomography (CT) attenuation value of 24.13 HU L g(-1), which is much better than that achieved using the commercial product iopromide (15.9 HU L g(-1)). The outstanding magnetic resonance (MR) imaging and CT imaging performances of the Mn3O4/PtOx NCs were proved through in vivo experiments. Histological examinations and blood circulation assays confirmed the good biosafety of the NCs. These novel findings showcase a brand-new strategy for fabricating excellent MON T-1 contrast agents (CAs) on the basis of the surface structure and they pave the way for their practical clinical applications in dual-modal imaging. |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000637697500027 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/121804]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Cai, Yunyu; Hong, Bo; Liang, Changhao |
| 作者单位 | 1.Chinese Acad Sci, Inst Solid State Phys, Anhui Key Lab Nanomat & Nanotechnol, Hefei 230031, Peoples R China 2.Univ Sci & Technol China, Hefei 230026, Peoples R China 3.Shanxi Med Univ, Hosp 1, Dept Ultrason Imaging, Taiyuan 030001, Shanxi, Peoples R China 4.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China 5.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, CAS Key Lab High Magnet Field & Ion Beam Phys Bio, Hefei 230031, Peoples R China 6.Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China 7.Chinese Acad Sci, Inst Solid State Phys, Key Lab Mat Phys, Hefei 230031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Sihan,Chen, Yaodong,Zhao, Xianglong,et al. Surface morphology and payload synergistically caused an enhancement of the longitudinal relaxivity of a Mn3O4/PtOx nanocomposite for magnetic resonance tumor imaging[J]. BIOMATERIALS SCIENCE,2021,9. |
| APA | Ji, Sihan.,Chen, Yaodong.,Zhao, Xianglong.,Cai, Yunyu.,Zhang, Xiaopeng.,...&Liang, Changhao.(2021).Surface morphology and payload synergistically caused an enhancement of the longitudinal relaxivity of a Mn3O4/PtOx nanocomposite for magnetic resonance tumor imaging.BIOMATERIALS SCIENCE,9. |
| MLA | Ji, Sihan,et al."Surface morphology and payload synergistically caused an enhancement of the longitudinal relaxivity of a Mn3O4/PtOx nanocomposite for magnetic resonance tumor imaging".BIOMATERIALS SCIENCE 9(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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