In situ pepsin-assisted needle assembly of magnetic-graphitic-nanocapsules for enhanced gastric retention and mucus penetration
文献类型：期刊论文
| 作者 | Cai, Xinqi2; Xu, Yiting2; Zhao, Lina3,4; Xu, Jiamei2; Li, Shengkai2; Wen, Chaoqi2; Xia, Xin2; Dong, Qian2; Hu, Xiaoxiao2; Wang, Xiaofeng3,4 |
| 刊名 | NANO TODAY
 |
| 出版日期 | 2021-02-01 |
| 卷号 | 36 |
| 关键词 | Harsh gastric environment Pepsin-assisted assembly Magnetic-graphitic-nanocapsule needle Gastric retention Mucus penetration |
| ISSN号 | 1748-0132 |
| DOI | 10.1016/j.nantod.2020.101032 |
| 通讯作者 | Chen, Zhuo(zhuochen@hnu.edu.cn) |
| 英文摘要 | Gastric environment is an extreme pH and enzyme-rich condition, which together with gastric mucus barrier and short retention time of oral medicine militate against effective oral drug delivery to lesion areas of gastric diseases. Assembly, especially shape -control assembly of magnetic nanoparticles potentially helps the site-selective drug molecule delivery. However, the harsh gastric condition, and cumbersome and strict requirements make the in situ reversible assembly remain challenging. Herein, synergistically pepsin-bridged and magnetic field -mediated morphological control of magnetic-graphitic-nanocapsules (MGNs) needle assembly (MNA) is developed in stomach for prolonged gastric retention and enhanced mucus penetration. The MNAs with good biocompatibility, large magnetic moments and unique needle shape are formed with the help of pepsin, demonstrating superior magnetic-driven capability to overcome gastric mucus barrier. Molecular dynamics simulations reveal binding modes between MGN and amino acid residues on either side of the pepsin, indicating pepsin acts as "bridge" allowing sufficient contact among MGNs and further facilitates the needle assembly. Moreover, anticancer drug doxorubicin (DOX)-loaded MNAs demonstrate superior targeted cancer cell killing ability and boosted DOX penetration in a mouse model, which promises good bioavailability of drug molecules. The versatile MNA-based platform offers a robust strategy for effective oral drug delivery and site-selective therapy of gastric diseases. (C) 2020 Elsevier Ltd. All rights reserved. |
| 资助项目 | National Natural Science Foundation of China[21522501] ; National Natural Science Foundation of China[31971311] ; National Natural Science Foundation of China[21727817] ; National Natural Science Foundation of China[61527806] ; National Natural Science Foundation of China[31701249] ; National Natural Science Foundation of China[31970692] ; Hunan Provincial Natural Science Foundation of China[2018JJ1007] ; Changsha Science and Technology Plan[kq2004009] ; High level foreign expert introduction program[GX20200018001] ; Science and Technology Development Fund, Macau[196/2017/A3] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000637808000024 |
| 出版者 | ELSEVIER SCI LTD |
| 资助机构 | National Natural Science Foundation of China ; Hunan Provincial Natural Science Foundation of China ; Changsha Science and Technology Plan ; High level foreign expert introduction program ; Science and Technology Development Fund, Macau |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/121938]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Chen, Zhuo |
| 作者单位 | 1.Univ Chinese Acad Sci, Inst Canc & Basic Med IBMC, Chinese Acad Sci, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 2.Hunan Univ, Mol Sci & Biomed Lab, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn,Coll Life Sci,Aptamer Engn, Changsha 410082, Hunan, Peoples R China 3.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 4.Univ Chinese Acad Sci, Beijing 101408, Peoples R China 5.Univ Macau, Fac Sci & Technol, Ave Univ, Taipa 999078, Macau, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cai, Xinqi,Xu, Yiting,Zhao, Lina,et al. In situ pepsin-assisted needle assembly of magnetic-graphitic-nanocapsules for enhanced gastric retention and mucus penetration[J]. NANO TODAY,2021,36. |
| APA | Cai, Xinqi.,Xu, Yiting.,Zhao, Lina.,Xu, Jiamei.,Li, Shengkai.,...&Tan, Weihong.(2021).In situ pepsin-assisted needle assembly of magnetic-graphitic-nanocapsules for enhanced gastric retention and mucus penetration.NANO TODAY,36. |
| MLA | Cai, Xinqi,et al."In situ pepsin-assisted needle assembly of magnetic-graphitic-nanocapsules for enhanced gastric retention and mucus penetration".NANO TODAY 36(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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