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Liquid biopsies to distinguish malignant from benign pulmonary nodules

文献类型：期刊论文

作者Tao, Rui4; Cao, Wei3; Zhu, Feng1; Nie, Jinfu2,5; Wang, Hongzhi2,5; Wang, Lixiang3; Liu, Pengcheng4; Chen, Hailong4; Hong, Bo2,5; Zhao, Dahai4
刊名THORACIC CANCER
出版日期2021-05-07
ISSN号1759-7706
关键词biomarker cell‐ free DNA liquid biopsy miRNA pulmonary nodule diagnosis
DOI10.1111/1759-7714.13982
通讯作者Hong, Bo(bhong@hmfl.ac.cn) ; Zhao, Dahai(zhaodahai@ahmu.edu.cn)
英文摘要Over the past decades, low-dose computed tomography (LD-CT) screening has been widely used for the early detection of lung cancer. Increasing numbers of indeterminate pulmonary nodules are now being discovered. However, it remains challenging to distinguish malignant from benign pulmonary nodules, especially those considered to be small or ground-glass (GGN) nodules. Liquid biopsies have been successfully applied in the diagnosis of advanced lung cancer, and the potential value for early detection of lung cancer has made great progress. Recent studies have demonstrated the value of various blood-based tumor biomarkers in determining the nature of pulmonary nodules, including cell-free DNA (cfDNA), microRNAs (miRNAs), circulating tumor cells (CTCs) and tumor-associated autoantibodies (AAbs). In this review, we summarize the latest progress of liquid biopsies, and their potential applications and challenges in the diagnosis of malignant pulmonary nodules.
资助项目Key Research and Development Project of Anhui Province[201904a07020064] ; Second Affiliated Hospital of Anhui Medical University[LHJJ202002] ; Center of Medical Physics and Technology of Hefei Institute of Physical Sciences of Chinese Academy of Sciences[LHJJ202002] ; National Natural Science Foundation of China[81872438] ; Hefei Innovation Project[J2018Y04] ; CAPTRA-Lung Research Funds[CAPTRALung2020004]
WOS研究方向Oncology ; Respiratory System
语种英语
出版者WILEY
WOS记录号WOS:000647855900001
资助机构Key Research and Development Project of Anhui Province ; Second Affiliated Hospital of Anhui Medical University ; Center of Medical Physics and Technology of Hefei Institute of Physical Sciences of Chinese Academy of Sciences ; National Natural Science Foundation of China ; Hefei Innovation Project ; CAPTRA-Lung Research Funds
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/122004]  
专题中国科学院合肥物质科学研究院
通讯作者Hong, Bo; Zhao, Dahai
作者单位1.Anhui Med Univ, Anhui Chest Hosp, Dept Thorac Surg, Thorac Clin Coll, Hefei, Peoples R China
2.Chinese Acad Sci, Anhui Prov Key Lab Med Phys & Technol, Inst Heath & Med Technol, Hefei Inst Phys Sci, 350 Shushanhu Rd, Hefei 230031, Peoples R China
3.Anhui Med Univ, Affiliated Hosp 2, Dept Cardiothorac Surg, Hefei, Peoples R China
4.Anhui Med Univ, Affiliated Hosp 2, Dept Resp & Crit Care Med, 678 Furong Rd, Hefei 230601, Peoples R China
5.Chinese Acad Sci, Hefei Canc Hosp, Hefei, Peoples R China
推荐引用方式
GB/T 7714		 Tao, Rui,Cao, Wei,Zhu, Feng,et al. Liquid biopsies to distinguish malignant from benign pulmonary nodules[J]. THORACIC CANCER,2021.
APA Tao, Rui.,Cao, Wei.,Zhu, Feng.,Nie, Jinfu.,Wang, Hongzhi.,...&Zhao, Dahai.(2021).Liquid biopsies to distinguish malignant from benign pulmonary nodules.THORACIC CANCER.
MLA Tao, Rui,et al."Liquid biopsies to distinguish malignant from benign pulmonary nodules".THORACIC CANCER (2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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