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The effect of ambient ozone on glucose-homoeostasis: A prospective study of non-diabetic older adults in Beijing

文献类型：期刊论文

作者Li, Ang1,2; Mei, Yayuan1,2; Zhao, Meiduo1,2; Xu, Jing1,2; Seery, Samuel3; Li, Runkui4,5; Zhao, Jiaxin1,2; Zhou, Quan1,2; Ge, Xiaoyu1,2; Xu, Qun1,2
刊名SCIENCE OF THE TOTAL ENVIRONMENT
出版日期2021-03-20
卷号761页码:13
关键词Glucose homeostasis Glucose metabolism disorder Longitudinal study O3
ISSN号0048-9697
DOI10.1016/j.scitotenv.2020.143308
通讯作者Xu, Qun(xuqun@ibms.cams.cn)
英文摘要Objective: To investigate potential effects of short- and medium-term exposure to low levels of ozone (O3) on glucose-homeostasis in non-diabetic older adults. Methods: 166 non-diabetic, older participants in Beijing were deemed eligible to partake in this longitudinal populalion-based study. Observations were recorded on three separate occasions from November 2016 up until January 2018. Concentrations of outdoor O3 were monaural throughout the slaty period. Biomarkers indicative of glucose-homeostasis, including fasting blood glucose, insulin, HbAlc, glycated albumin percentage (glycated albumin/albumin), HOMA-IR and HOMA-B were measured at 3 sessions. A linear mixed effects model with random effects was adopted to quantify the effect O3 across a comprehensive set of glucose homeostasis markers. Results: Short-term O3 exposure positively associated with increased fasting blood glucose, insulin, HOMA-IR and HOMA-B. The effect on glucose occurred at 3-, 5-, 6- and 7-days, although the largest effect manifested on 6-days (5.6%, 95% CI: 1.4, 9.9). Significant associations with both insulin and HOMA-IR were observed on the 3- and 4 days. For HOMA-B, positive associations were identified from 3- to 7-days with estimates ranging from 40.0% (95% CI: 23, 91.5) to 83.1% (95%, Cl, 25.3, 1675). Stratification suggests that women may be more susceptible to short-term O3 exposure. There does not appear to be a significant association between O3 and glucose homeostasis in medium-term exposures. Conclusions: In this study, we found that 03 exposure is at least partially associated with type II diabetes in older adults with no prior history of this condition. 03 therefore appears to be a potential risk factor, which is a particular concern when we consider the rise in global concentrations. Evidence also suggests that women may be more susceptible to short-term O3 exposure although we are not quite sure why. Future research may look to investigate this phenomenon further. (C) 2020 Elsevier B.V. All rights reserved.
WOS关键词AIR-POLLUTION PREVENTION ; CONTROL ACTION PLAN ; INSULIN-RESISTANCE ; OXIDATIVE STRESS ; DIABETES-MELLITUS ; GLYCATED ALBUMIN ; BLOOD-PRESSURE ; EXPOSURE ; MORTALITY ; PM2.5
资助项目ChinaMedical Board[15-230] ; China Prospective cohort study of Air pollution and health effects in Typical areas (C-PAT)[MEE-EH-20190802] ; Fundamental Research Funds for the Central Universities[3332019147] ; National Key Research and Development Program of China[2017YFB0503605] ; PUMC Fundamental Research Funds for the Central Universities, China[3332019144] ; Peking UnionMedical College Graduate Innovation Fund[2019-1004-02] ; Chinese Academy of Medical Science Innovation Fund for Medical Sciences[2017-I2M-1-009] ; Program of Science and Technology Service Network Initiative (STS) of Chinese Academy of Sciences[Y88Q0300YD] ; National Natural Science Foundation of China[41771435] ; China Scholarship Council[201704910297]
WOS研究方向Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000607780900108
出版者ELSEVIER
资助机构ChinaMedical Board ; China Prospective cohort study of Air pollution and health effects in Typical areas (C-PAT) ; Fundamental Research Funds for the Central Universities ; National Key Research and Development Program of China ; PUMC Fundamental Research Funds for the Central Universities, China ; Peking UnionMedical College Graduate Innovation Fund ; Chinese Academy of Medical Science Innovation Fund for Medical Sciences ; Program of Science and Technology Service Network Initiative (STS) of Chinese Academy of Sciences ; National Natural Science Foundation of China ; China Scholarship Council
源URL[http://ir.igsnrr.ac.cn/handle/311030/136449]  
专题中国科学院地理科学与资源研究所
通讯作者Xu, Qun
作者单位1.Chinese Acad Med Sci, Peking Union Med Coll, Dept Epidemiol & Biostat, Inst Basic Med Sci,Sch Basic Med, Beijing 100005, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll, Ctr Environm & Hlth Sci, Beijing 100005, Peoples R China
3.Chinese Acad Med Sci & Peking Union Med Coll, Sch Humanities & Social Sci, Beijing 100005, Peoples R China
4.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Li, Ang,Mei, Yayuan,Zhao, Meiduo,et al. The effect of ambient ozone on glucose-homoeostasis: A prospective study of non-diabetic older adults in Beijing[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2021,761:13.
APA Li, Ang.,Mei, Yayuan.,Zhao, Meiduo.,Xu, Jing.,Seery, Samuel.,...&Xu, Qun.(2021).The effect of ambient ozone on glucose-homoeostasis: A prospective study of non-diabetic older adults in Beijing.SCIENCE OF THE TOTAL ENVIRONMENT,761,13.
MLA Li, Ang,et al."The effect of ambient ozone on glucose-homoeostasis: A prospective study of non-diabetic older adults in Beijing".SCIENCE OF THE TOTAL ENVIRONMENT 761(2021):13.

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来源：地理科学与资源研究所

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