Environmental titanium exposure and reproductive health: Risk of low birth weight associated with maternal titanium exposure from a nested case-control study in northern China
文献类型：期刊论文
| 作者 | Jin, Yu3,4; Li, Zhiyi2; An, Hang3,4; Pang, Yiming3,4; Li, Kexin2; Zhang, Yali3,4; Zhang, Le3,4; Yan, Lailai1; Wang, Bin3,4; Ye, Rongwei3,4 |
| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2021-01-15 |
| 卷号 | 208页码:7 |
| 关键词 | Titanium Low birth weight Lipids Oxidative stress Pregnancy |
| ISSN号 | 0147-6513 |
| DOI | 10.1016/j.ecoenv.2020.111632 |
| 通讯作者 | Ye, Rongwei(yerw@bjmu.edu.cn) |
| 英文摘要 | Titanium (Ti) is commonly used in additives in the form of titanium dioxide (TiO2). However, our understanding of the effect of Ti on reproductive health remains limited. This nested case-control study, performed in a Ti mining exposure field, investigated the association between maternal blood Ti concentration and the risk of low birth weight (LBW), as well as the potential biological mechanism. A total of 45 women who delivered LBW infants (cases) and 352 women with normal birth weight infants (controls) were included. We collected maternal peripheral blood samples in the first or early second trimester to measure Ti concentration in serum (Ti-sr) and blood cells (Ti-bc), as well as inflammatory, lipid, and oxidative stress biomarkers thereof. The demographic characteristics of the women included in the study were also obtained. The results showed that the median total blood Ti concentration (Ti-tb) in the case group was significantly higher than that in the control group (134 vs. 129 ng/mL, P = 0.039). A higher Titb level was associated with a greater risk of LBW [odds ratio = 2.62; 95% confidence interval (CI): 1.16-5.90], but no such association was observed for Ti-sr or Ti-bc after adjusting for potential confounders. The serum lipid biomarkers TC, TG, and total lipids (TL) were all negatively associated with Ti-sr and Ti-tb. Serum 8-OHdG was positively associated with Ti-bc. We concluded that a high Ti-tb during early pregnancy may increase the risk of LBW. Lipid metabolism and oxidative stress may play an important role in the adverse health effects associated with Ti exposure. Thus, our results merit more attention to the probable adverse effects of titanium exposure during pregnancy. |
| WOS关键词 | UMBILICAL-CORD BLOOD ; DIOXIDE NANOPARTICLES ; TISSUE DISTRIBUTION ; OXIDATIVE STRESS ; PREGNANT-WOMEN ; AIR-POLLUTION ; IN-VITRO ; METALS ; PLASMA ; ADULTS |
| 资助项目 | National Natural Science Foundation of China[41771527] ; National Natural Science Foundation of China[81673177] |
| WOS研究方向 | Environmental Sciences & Ecology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000604136800001 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.igsnrr.ac.cn/handle/311030/137870]  |
| 专题 | 中国科学院地理科学与资源研究所 |
| 通讯作者 | Ye, Rongwei |
| 作者单位 | 1.Peking Univ, Sch Publ Hlth, Dept Lab Sci & Technol, Beijing 100191, Peoples R China 2.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Beijing 100101, Peoples R China 3.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China 4.Peking Univ, Inst Reprod & Child Hlth, Key Lab Reprod Hlth, Natl Hlth Commiss Peoples Republ China, Beijing 100191, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Yu,Li, Zhiyi,An, Hang,et al. Environmental titanium exposure and reproductive health: Risk of low birth weight associated with maternal titanium exposure from a nested case-control study in northern China[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2021,208:7. |
| APA | Jin, Yu.,Li, Zhiyi.,An, Hang.,Pang, Yiming.,Li, Kexin.,...&Ren, Aiguo.(2021).Environmental titanium exposure and reproductive health: Risk of low birth weight associated with maternal titanium exposure from a nested case-control study in northern China.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,208,7. |
| MLA | Jin, Yu,et al."Environmental titanium exposure and reproductive health: Risk of low birth weight associated with maternal titanium exposure from a nested case-control study in northern China".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 208(2021):7. |
入库方式： OAI收割
来源：地理科学与资源研究所
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