Assessment of reactive oxygen species production and genotoxicity of rare earth mining dust: Implications for public health and mining management
文献类型：期刊论文
| 作者 | Tian, Shuhan1,2,3; Li, Kexin2,3; Moller, Peter1; Ying, Samantha C.4; Wang, Lingqing2,3 ; Li, Zhiyi2,3; Roursgaard, Martin1; Liang, Tao2,3
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| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
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| 出版日期 | 2020-10-20 |
| 卷号 | 740页码:10 |
| ISSN号 | 0048-9697 |
| 关键词 | Rare earth elements REE Mine pollution Genotoxicity ROS production Source apportionment |
| DOI | 10.1016/j.scitotenv.2020.139759 |
| 通讯作者 | Roursgaard, Martin(mwro@sund.ku.dk) ; Liang, Tao(liangt@igsnrr.ac.cn) |
| 英文摘要 | Mining rare earth elements (REEs) can release large amounts of metal(loid)-rich dust, which can pose significant health risks to local residents. However, compared to other types of particulates, toxicity of mining dust has been largely overlooked. To provide experimental evidence on toxicity of REE mine dust, the study assessed the oxidative stress potential and genotoxicity of inhalable particles collected in a REE mining area, and associated toxicological response with source compositions. Both source types (i.e., mine and tailing area) and distances from source (i.e., industrial and residential areas) were considered when selecting the 44 sampling sites. The particle samples contained 2.3-3.5 folds higher concentrations of tested metal(loid)s than background concentrations in soil. Specially, elevated Fe, REEs, Cd, Pb were found. In spite of low cytotoxicity in lung epithelial A549 cells, there was increased cellular ROS production by of particle exposure. Samples with higher mining-originated source contributions (Provenance Index <0.3) had higher cellular ROS production (1.72 fold, 95%CI: 1.66-1.79 fold) than samples with lower mining contributions (158 fold, 95%CI: 152-1.65 fold). The factors soil (similar to 46%), mine (similar to 22%), and heavy metal (similar to 20%) sources were recognized by source apportionment analysis as the main contributors to cellular ROS production; importantly, mine and heavy metal sources counted more in industrial samples. While samples generated genotoxicity, there were no differences in DNA damage between the location groups of sampling. Collectively, the results indicate that particles in mining areas may cause ROS production and DNA damage in lung cells depending on mine dust. Coupled with the long-range transportation potential of mine dust, safety measures on open pit and dust disposal sites should be adopted. (C) 2020 Elsevier B.V. All rights reserved. |
| WOS关键词 | AMBIENT PARTICULATE MATTER ; INNER-MONGOLIA ; LOS-ANGELES ; ORAL BIOACCESSIBILITY ; OXIDATIVE DAMAGE ; REDOX ACTIVITY ; AIR-POLLUTION ; SCALP HAIR ; ELEMENTS ; EXPOSURE |
| 资助项目 | National Natural Science Foundation of China[41571473] ; National Natural Science Foundation of China[41401591] ; USDA NIFA Hatch Project[CA-R-ENS-5151-H] |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000562059800015 |
| 资助机构 | National Natural Science Foundation of China ; USDA NIFA Hatch Project |
| 源URL | [http://ir.igsnrr.ac.cn/handle/311030/158010]  |
| 专题 | 中国科学院地理科学与资源研究所 |
| 通讯作者 | Roursgaard, Martin; Liang, Tao |
| 作者单位 | 1.Univ Copenhagen, Fac Hlth & Med Sci, Dept Publ Hlth, Sect Environm Hlth, Oster Farimagsgade 5A, DK-1014 Copenhagen K, Denmark 2.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Key Lab Land Surface Pattern & Simulat, 11A Datun Rd, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Univ Calif Riverside, Dept Environm Sci, Riverside, CA 92521 USA |
| 推荐引用方式 GB/T 7714 | Tian, Shuhan,Li, Kexin,Moller, Peter,et al. Assessment of reactive oxygen species production and genotoxicity of rare earth mining dust: Implications for public health and mining management[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2020,740:10. |
| APA | Tian, Shuhan.,Li, Kexin.,Moller, Peter.,Ying, Samantha C..,Wang, Lingqing.,...&Liang, Tao.(2020).Assessment of reactive oxygen species production and genotoxicity of rare earth mining dust: Implications for public health and mining management.SCIENCE OF THE TOTAL ENVIRONMENT,740,10. |
| MLA | Tian, Shuhan,et al."Assessment of reactive oxygen species production and genotoxicity of rare earth mining dust: Implications for public health and mining management".SCIENCE OF THE TOTAL ENVIRONMENT 740(2020):10. |
入库方式： OAI收割
来源：地理科学与资源研究所
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