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Associations between air pollutant exposure and renal function: A prospective study of older adults without chronic kidney disease

文献类型：期刊论文

作者Li, Ang1,3; Mei, Yayuan1,3; Zhao, Meiduo1,3; Xu, Jing1,3; Li, Runkui2,4; Zhao, Jiaxin1,3; Zhou, Quan1,3; Ge, Xiaoyu1,3; Xu, Qun1,3
刊名ENVIRONMENTAL POLLUTION
出版日期2021-05-15
卷号277页码:10
关键词Nitrogen dioxide (NO2) Chronic kidney disease (CKD) Estimated glomerular filtration rate (eGFR) Urinary albumin/creatinine ratio (UACR)
ISSN号0269-7491
DOI10.1016/j.envpol.2021.116750
通讯作者Xu, Qun(xuqun@ibms.cams.cn)
英文摘要We used real-world exposure scenarios to evaluate the effect of six ambient air pollutant (PM2.5, PM10, NO2, SO2, CO, and O-3) exposure on renal function among older adults without chronic kidney disease (CKD). We recruited 169 older adults without CKD in Beijing, China, for a longitudinal study from 2016 to 2018. The Modification of Diet in Renal Disease (MDRD) and the Chronic Kidney Disease Epidemiology Collaboration (EPI) equations were employed to derive the estimated glomerular filtration rate (eGFR). A linear mixed-effects model with random intercepts for participants was employed to determine the effects of air pollutants on renal function evaluated on the basis of eGFR and urinary albumin/creatinine ratio at different exposure windows (1-, 2-, 3-, 5-, 7-, 14-, 28-, 45-, and 60-days moving averages). An interquartile range (IQR) increase in NO2 for was associated with significant decreases of in eGFR (MDRD equation) [percentage changes: -4.49 (95% confidence interval: -8.44, -0.37), -5.51 (-10.43, -0.33), -2.26 (-4.38, -0.08), -3.71 (-6.67, -0.65), -5.44 (-9.58, -1.11), -5.50 (-10.24, -0.51), -6.15 (-10.73, -1.33), and -6.34 (-11.17, -1.25) for 1-, 2-, 5-, 7-, 14-, 28-, 45-, and 60-days moving averages, respectively] and in eGFR (EPI equation) [percentage changes: -5.04 (-7.09, -2.94), -6.25 (-8.81, - 3.62), -5.16 (-7.34, -2.92), -5.10 (-7.85, -2.28), -5.83 (-8.23, -3.36), -6.04 (-8.55, -3.47) for 1-, 2-, 14-, 28-, 45-, and 60-days moving averages, respectively]. In two-pollutant model, only the association of NO2 exposure with eGFR remained robust after adjustment for any other pollutant. This association was stronger for individuals with hypertension for the EPI equation or BMI <25 kg/m(2) for the MDRD equation at lags 1 and 1-2. Our findings suggest that NO2 exposure is associated with eGFR reduction among older adults without CKD for short (1-, 2-days) and medium (14-, 28-, 45-, 60-days) term exposure periods; thus, NO2 exposure may contribute to renal impairment. (c) 2021 Elsevier Ltd. All rights reserved.
资助项目China Prospective cohort study of Air pollution and health effects in Typical areas (C-PAT)[MEE-EH-20190802] ; Fundamental Research Funds for the Central Universities[3332019147] ; Peking Union Medical College Graduate Innovation Fund[2019-1004-02] ; China Medical Board[15-230] ; Chinese Academy of Medical Science Innovation Fund for Medical Sciences[2017-I2M-1-009] ; National Key Research and Development Program of China[2017YFB0503605] ; National Natural Science Foundation of China[41771435]
WOS研究方向Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000637737100017
出版者ELSEVIER SCI LTD
资助机构China Prospective cohort study of Air pollution and health effects in Typical areas (C-PAT) ; Fundamental Research Funds for the Central Universities ; Peking Union Medical College Graduate Innovation Fund ; China Medical Board ; Chinese Academy of Medical Science Innovation Fund for Medical Sciences ; National Key Research and Development Program of China ; National Natural Science Foundation of China
源URL[http://ir.igsnrr.ac.cn/handle/311030/161800]  
专题中国科学院地理科学与资源研究所
通讯作者Xu, Qun
作者单位1.Chinese Acad Med Sci, Peking Union Med Coll, Ctr Environm & Hlth Sci, Beijing 100005, Peoples R China
2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China
3.Chinese Acad Med Sci, Sch Basic Med, Peking Union Med Coll, Dept Epidemiol & Biostat,Inst Basic Med Sci, Beijing 100005, Peoples R China
4.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Li, Ang,Mei, Yayuan,Zhao, Meiduo,et al. Associations between air pollutant exposure and renal function: A prospective study of older adults without chronic kidney disease[J]. ENVIRONMENTAL POLLUTION,2021,277:10.
APA Li, Ang.,Mei, Yayuan.,Zhao, Meiduo.,Xu, Jing.,Li, Runkui.,...&Xu, Qun.(2021).Associations between air pollutant exposure and renal function: A prospective study of older adults without chronic kidney disease.ENVIRONMENTAL POLLUTION,277,10.
MLA Li, Ang,et al."Associations between air pollutant exposure and renal function: A prospective study of older adults without chronic kidney disease".ENVIRONMENTAL POLLUTION 277(2021):10.

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来源：地理科学与资源研究所

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