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Greenness exposure and all-cause mortality during multi-drug resistant tuberculosis treatment: A population-based cohort study

文献类型：期刊论文

作者Ge, Erjia2; Gao, Jianhui1; Ren, Zhoupeng3; Liu, Xin4; Luo, Ming5; Zhong, Jieming6; Fei, Fangrong6; Chen, Bin7; Wang, Xiaomeng7; Wei, Xiaolin8
刊名SCIENCE OF THE TOTAL ENVIRONMENT
出版日期2021-06-01
卷号771页码:8
关键词Multidrug resistant tuberculosis All-cause mortality Greenness exposure PM2.5
ISSN号0048-9697
DOI10.1016/j.scitotenv.2021.145422
通讯作者Wang, Xiaomeng(xmwang@cdc.zj.cn) ; Wei, Xiaolin(xiaolin.wei@utoronto.ca) ; Peng, Ying(ypeng@cdc.zj.cn)
英文摘要Background: Living closer to greenness were thought to benefit various health outcomes. We aimed to assess the association between residential greenness and mortality among patients undergoing multidrug resistant tuberculosis (MDR-TB) treatment. Methods: We enrolled all local MDR-TB patients reported in Zhejiang, China from 2009 to 2017 and followed them throughout the treatment. We calculated the contemporaneous normalized difference vegetation index (NDVI) in the 250 and 500 m radius around patient's residence. Cox proportional hazards regression models with time-varying NDVI were used to assess the impact of greenness exposure on all-cause mortality during MDR-TB treatment, adjusting for potential individual and contextual covariates. Results: We ascertained 1,621 activeMDR-TB cases, which contributed 3036 person-years at risk with an average follow-up of 684 days (s.d. 149 days) per patient. Among them, there were 163 deaths during follow-up, representing a crude mortality rate of 537 deaths per 10,000 person-years. Patients exposed to the second quintile (Q2) of greenness within the 500 m buffer had around 64% reducedmortality risk over the lowest quintile of greennesswith hazard ratio (HR) = 0.364 (95% CI: 0.109-1.22). In lower nighttime light (NTL) areas, the hazard ratios (HR) per quintile increase in NDVI within the 500 m buffer were Q2: 0.35 (95% CI: 0.10-1.18), Q3: 0.24 (95% CI: 0.09-0.66), Q4: 0.26 (95% CI: 0.10-0.69), and Q5: 0.26 (95% CI: 0.10-0.71) relevant to the lowest quintile Q1, with a trend of p-value <= 0.01. Patientswho were female, younger (<60 years), resided in urban areas, or had high PM2.5 (i.e. particles with diagram <= 2.5 mu m) exposure were more likely to benefit from greenness exposure. Associations were neither observed with NDVI in the 250 m buffer nor for patients living in higher NTL areas. There was a non-linear exposure-response relationship between greenness and deaths with p-value <= 0.05. Conclusion: Increasing greenness exposure along with medical treatment reduces all-cause mortality among patients living in lower NTL areas. (C) 2021 Elsevier B.V. All rights reserved.
资助项目Zhejiang Provincial Medical and Health Project[2019RC135] ; State Key Laboratory of Health Technology Assessment, Fudan University[FHTA2019-05] ; National Nature Science Foundation of China[71640019]
WOS研究方向Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000627895900127
出版者ELSEVIER
资助机构Zhejiang Provincial Medical and Health Project ; State Key Laboratory of Health Technology Assessment, Fudan University ; National Nature Science Foundation of China
源URL[http://ir.igsnrr.ac.cn/handle/311030/161924]  
专题中国科学院地理科学与资源研究所
通讯作者Wang, Xiaomeng; Wei, Xiaolin; Peng, Ying
作者单位1.Univ Toronto, Dalla Lana Sch Publ Hlth, Div Biostat, Toronto, ON, Canada
2.Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, Toronto, ON, Canada
3.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, Beijing, Peoples R China
4.Southwest Petr Univ, Sch Geosci & Technol, Chengdu, Sichuan, Peoples R China
5.Sun Yat Sen Univ, Sechool Geog & Planning, Guangzhou, Guangdong, Peoples R China
6.Zhejiang Prov Ctr Dis Control & Prevent, Div Chron Dis, Hangzhou, Zhejiang, Peoples R China
7.Zhejiang Prov Ctr Dis Control & Prevent, Div TB, 3399 Bin Sheng Rd, Hangzhou, Zhejiang, Peoples R China
8.Univ Toronto, Dalla Lana Sch Publ Hlth, Inst Hlth Policy & Evaluat, Div Clin Publ Hlth, Toronto, ON, Canada
推荐引用方式
GB/T 7714		 Ge, Erjia,Gao, Jianhui,Ren, Zhoupeng,et al. Greenness exposure and all-cause mortality during multi-drug resistant tuberculosis treatment: A population-based cohort study[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2021,771:8.
APA Ge, Erjia.,Gao, Jianhui.,Ren, Zhoupeng.,Liu, Xin.,Luo, Ming.,...&Peng, Ying.(2021).Greenness exposure and all-cause mortality during multi-drug resistant tuberculosis treatment: A population-based cohort study.SCIENCE OF THE TOTAL ENVIRONMENT,771,8.
MLA Ge, Erjia,et al."Greenness exposure and all-cause mortality during multi-drug resistant tuberculosis treatment: A population-based cohort study".SCIENCE OF THE TOTAL ENVIRONMENT 771(2021):8.

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来源：地理科学与资源研究所

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