Change detection (CD) aims to identify the differences between multitemporal images acquired over the same geographical area at different times. With the advantages of requiring no cumbersome labeled change information, unsupervised CD has attracted extensive attention of researchers. Multitemporal images tend to have different resolutions as they are usually captured at different times with different sensor properties. It is difficult to directly obtain one pixelwise change map for two images with different resolutions, so current methods usually resize multitemporal images to a unified size. However, resizing operations change the original information of pixels, which limits the final CD performance. This article aims to detect changes from multitemporal images in the originally different resolutions without resizing operations. To achieve this, a cross-resolution difference learning method is proposed. Specifically, two cross-resolution pixelwise difference maps are generated for the two different resolution images and fused to produce the final change map. First, the two input images are segmented into individual homogeneous regions separately due to different resolutions. Second, each pixelwise difference map is produced according to two measure distances, the mutual information distance and the deep feature distance, between image regions in which the pixel lies. Third, the final binary change map is generated by fusing and binarizing the two cross-resolution difference maps. Extensive experiments on four datasets demonstrate the effectiveness of the proposed method for detecting changes from different resolution images. IEEE